A mathematical model of pHi regulation in central CO2 -: Chemoreception

被引：0
|
作者：
Cordovez, Juan M. [1 ]
Clausen, Chris [1 ]
Moore, Leon C. [1 ]
Solomon, Irene C. [1 ]
机构：
[1] SUNY Stony Brook, Dept Physiol & Biophys, Stony Brook, NY 11794 USA
来源：
INTEGRATION IN RESPIRATORY CONTROL: FROM GENES TO SYSTEMS | 2008年 / 605卷
关键词：
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
In CO(2) chemosensitive neurons, an increase in CO, (hypercapnia) leads to a maintained reduction in intracellular pH (pH) while in non-chemosensitive neurons pH(i) recovery is observed. The precise mechanisms for the differential regulation of pH(i) recovery between these cell populations remain to be identified; however, studies have begun to explore the role of Na(+)/H(+) exchange (NHE). Here, we compare the results of two different formulations of a mathematical model to begin to explore pHi regulation in central CO(2) chemoreception.
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页码：306 / 311
页数：6
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