Mixed signals from the cell's antennae: primary cilia in cancer

被引：75
作者：
Eguether, Thibaut [1 ]
Hahne, Michael [2 ]
机构：
[1] PSL Res Univ, Sorbonne Univ, Lab Biomol LBM, Ecole Normale Super,CNRS,INSERM,APHP, Paris, France
[2] Univ Montpellier, CNRS, IGMM, Montpellier, France
来源：
EMBO REPORTS | 2018年 / 19卷 / 11期
关键词：
cancer; Hedgehog; primary cilia; PANCREATIC DUCTAL ADENOCARCINOMA; SONIC HEDGEHOG PATHWAY; VON-HIPPEL-LINDAU; STEM-CELLS; INTRAFLAGELLAR TRANSPORT; TUMOR-SUPPRESSOR; BREAST-CANCER; MAINTAIN CILIA; CHOROID-PLEXUS; MEDULLOBLASTOMA;
D O I：
10.15252/embr.201846589
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Primary cilia (PC) are antenna-like organelles that protrude from most mammalian cells. They are essential for the regulation of several signaling pathways such as Hedgehog and WNT. It is therefore not surprising that a dysfunction of PC is frequently associated with pathologies. Originally, PC were found to be involved in a variety of diseases commonly referred to as ciliopathies including cystic kidney diseases. Evidence is accumulating that PC play also an important role in cancer formation and regulation, which is the focus of this review.
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页数：15
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共 130 条
[1]   Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancer [J].
Bailey, J. M. ;
Mohr, A. M. ;
Hollingsworth, M. A. .
ONCOGENE, 2009, 28 (40) :3513-3525
[2]   Basal cell carcinoma pathogenesis and therapy involving hedgehog signaling and beyond [J].
Bakshi, Anshika ;
Chaudhary, Sandeep C. ;
Rana, Mehtab ;
Elmets, Craig A. ;
Athar, Mohammad .
MOLECULAR CARCINOGENESIS, 2017, 56 (12) :2543-2557
[3]   Kif3a is necessary for initiation and maintenance of medulloblastoma [J].
Barakat, Monique T. ;
Humke, Eric W. ;
Scott, Matthew P. .
CARCINOGENESIS, 2013, 34 (06) :1382-1392
[4]   CILIATED SECRETORY CELLS IN PARS DISTALIS OF MOUSE HYPOPHYSIS [J].
BARNES, BG .
JOURNAL OF ULTRASTRUCTURE RESEARCH, 1961, 5 (05) :453-&
[5]  
Basten Sander G, 2013, Cilia, V2, P2, DOI 10.1186/2046-2530-2-2
[6]   Medulloblastoma in children and adolescents: a systematic review of contemporary phase I and II clinical trials and biology update [J].
Bautista, Francisco ;
Fioravantti, Victoria ;
de Rojas, Teresa ;
Carceller, Fernando ;
Madero, Luis ;
Lassaletta, Alvaro ;
Moreno, Lucas .
CANCER MEDICINE, 2017, 6 (11) :2606-2624
[7]   Disruption of the ciliary GTPase Arl13b suppresses Sonic hedgehog overactivation and inhibits medulloblastoma formation [J].
Bay, Sarah N. ;
Long, Alyssa B. ;
Caspary, Tamara .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (07) :1570-1575
[8]   Primary cilia regulate Gli/Hedgehog activation in pancreas [J].
Cervantes, Sara ;
Lau, Janet ;
Cano, David A. ;
Borromeo-Austin, Cecilia ;
Hebrok, Matthias .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (22) :10109-10114
[9]   Modulation of Ciliary Phosphoinositide Content Regulates Trafficking and Sonic Hedgehog Signaling Output [J].
Chavez, Marcelo ;
Ena, Sabrina ;
Van Sande, Jacqueline ;
d'Exaerde, Alban de Kerchove ;
Schurmans, Stephane ;
Schiffmann, Serge N. .
DEVELOPMENTAL CELL, 2015, 34 (03) :338-350
[10]   Primary Cilia and Coordination of Receptor Tyrosine Kinase (RTK) and Transforming Growth Factor β (TGF-β) Signaling [J].
Christensen, Soren T. ;
Morthorst, Stine K. ;
Mogensen, Johanne B. ;
Pedersen, Lotte B. .
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2017, 9 (06)
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