Plasma Amino Acid Concentrations in Patients with Alcohol and/or Cocaine Use Disorders and Their Association with Psychiatric Comorbidity and Sex

被引:0
作者
Garcia-Marchena, Nuria [1 ,2 ]
Marcos, Alberto [3 ]
Flores-Lopez, Maria [1 ,4 ]
Moreno-Fernandez, Mario [3 ]
Requena-Ocana, Nerea [1 ,5 ]
Porras-Perales, Oscar [1 ,4 ]
Torres-Galvan, Sandra [1 ,6 ]
Araos, Pedro [1 ,4 ]
Serrano, Antonia [1 ]
Muga, Roberto [2 ]
Jesus Ruiz-Ruiz, Juan [7 ]
Rodriguez de Fonseca, Fernando [1 ]
Ambrosio, Emilio [3 ]
Javier Pavon-Moron, Francisco [1 ,8 ,9 ]
机构
[1] Hosp Reg Univ Malaga, Inst Invest Biomed Malaga IBIMA, UGC Salud Mental, Malaga 29590, Spain
[2] Inst Invest Ciencies Salut Germans Trias & Pujol, Serv Med Interna, Unidad Adicc, Badalona 08916, Spain
[3] Univ Nacl Educ Distancia UNED, Fac Psicol, Dept Psicobiol, Madrid 28040, Spain
[4] Univ Malaga UMA, Fac Psicol, Dept Psicobiol & Metodol Ciencias Comportamiento, Malaga 29010, Spain
[5] Univ Complutense Madrid, Fac Psicol, Dept Psicobiol, Madrid 28223, Spain
[6] Univ Complutense Madrid, Fac Farm, Madrid 28040, Spain
[7] Diputac Prov Malaga, Ctr Prov Drogodependencias Malaga, Malaga 29010, Spain
[8] Hosp Univ Virgen Victoria, Inst Invest Biomed Malaga IBIMA, UGC Corazon, Malaga 29010, Spain
[9] Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Cardiovasc CIB, Madrid 28029, Spain
关键词
abstinence; alcohol use disorder; amino acids; biomarker; CE-LIF; cocaine use disorder; cross-sectional study; PRISM; psychiatric comorbidity; sex; SUBSTANCE USE DISORDERS; NMDA-RECEPTOR; ETHANOL SENSITIVITY; RESEARCH INTERVIEW; DEPENDENT PATIENTS; POLYSUBSTANCE USE; MENTAL-DISORDERS; FYN-KINASE; DRUG-USE; GLUTAMATE;
D O I
10.3390/biomedicines10051137
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
(1) Background: Co-occurrence of mental and substance use disorders (SUD) is prevalent, but complicates their clinical courses, and specific biomarkers are required. Amino acids are altered in primary mental disorders; however, little is known about SUD and psychiatric comorbidity. Because most psychiatric disorders and biomarkers show sex differences, we investigated amino acids in men and women with alcohol and/or cocaine use disorders (AUD and/or CUD) and psychiatric comorbidity. (2) Methods: A cross-sectional study was conducted in 295 participants, who were divided into four groups (AUD, n = 60; CUD, n = 41; AUD + CUD, n = 64; and control, n = 130). Participants were clinically assessed, and plasma amino acid concentrations were analyzed in relation to sex, diagnosis of SUD and psychiatric comorbidity (3) Results: In the total sample, there were sex differences, and women showed lower Iso, Leu, Gln and Glu than men. While patients with CUD and AUD + CUD had higher Glu, Gly, Orn and Ser than controls, patients with AUD showed no differences. In SUD, patients with psychiatric comorbidity had lower Orn and higher Ala than non-comorbid patients in the AUD group. (4) Conclusions: There was a dysregulation of plasma amino acids in abstinent patients with SUD. However, our results suggest the importance of considering the clinical characteristics and sex in the validity of amino acids as potential biomarkers for SUD.
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页数:20
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