Cell adhesion molecules: Key players in memory consolidation?

被引：46

作者：

Welzl, H ^{[1
]}

Stork, O

机构：

[1] Univ Zurich, Inst Anat, Div Neuroanat & Behav, CH-8057 Zurich, Switzerland

[2] Univ Magdeburg, Inst Physiol, Sch Med, D-39106 Magdeburg, Germany

来源：

NEWS IN PHYSIOLOGICAL SCIENCES | 2003年 / 18卷

关键词：

D O I：

10.1152/nips.01422.2002

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Experimental evidence implies that L1 and neural cell adhesion molecule (NCAM) are involved in long-term memory formation. Changes in their expression and glycosylation appear to modify the synaptic strength underlying memory consolidation. Interference with L1 and NCAM function in a variety of learning tasks in different species severely attenuates memory consolidation, indicating their involvement in an evolutionary conserved mechanism of neural plasticity.

引用

页码：147 / 150

页数：4

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