Environmental Fe, Ti, Al, Cu, Hg, Bi, and Si Nanoparticles in the Atrioventricular Conduction Axis and the Associated Ultrastructural Damage in Young Urbanites: Cardiac Arrhythmias Caused by Anthropogenic, Industrial, E-Waste, and Indoor Nanoparticles

被引：12

作者：

Calderon-Garciduenas, Lilian ^{[1
,2
]}

Gonzalez-Maciel, Angelica ^{[3
]}

Reynoso-Robles, Rafael ^{[3
]}

Luis Rodriguez-Lopez, Jose ^{[4
]}

Silva-Pereyra, Hector G. ^{[4
]}

Labrada-Delgado, Gladis J. ^{[4
]}

Perez-Guille, Beatriz ^{[3
]}

Eugenia Soriano-Rosales, Rosa ^{[3
]}

Jimenez-Bravo Luna, Miguel Angel ^{[3
]}

Brito-Aguilar, Rafael ^{[2
]}

Mukherjee, Partha S. ^{[5
]}

Gayosso-Chavez, Carlos ^{[6
]}

Delgado-Chavez, Ricardo

机构：

[1] Univ Montana, Missoula, MT 59812 USA

[2] Univ Valle Mexico, Ciudad De Mexico 14370, Mexico

[3] Inst Nacl Pediat, Ciudad De Mexico 04530, Mexico

[4] Inst Potosino Invest Cient & Tecnol AC, San Luis Potosi 78216, San Luis Potosi, Mexico

[5] Indian Stat Inst, Kolkata 700108, India

[6] Hosp HMG, Cardiol Dept, Ciudad De Mexico 04380, Mexico

来源：

ENVIRONMENTAL SCIENCE & TECHNOLOGY | 2021年 / 55卷 / 12期

关键词：

air pollution; atrioventricular AV node; cardiac arrhythmias; glycocalyx; e-waste; indoor pollution; nanoparticles; reentry tachycardia AVNRT; SARS-CoV-2; heart pacemakers; Metropolitan Mexico City; young urbanites; ULTRAFINE PARTICLES; EXPRESSION; POLLUTANTS; EXPOSURES; VEHICLES; HEART; FINE; NODE;

D O I：

10.1021/acs.est.1c01733

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Air pollution exposure is a risk factor for arrhythmia. The atrioventricular (AV) conduction axis is key for the passage of electrical signals to ventricles. We investigated whether environmental nanoparticles (NPs) reach the AV axis and whether they are associated with ultrastructural cell damage. Here, we demonstrate the detection of the shape, size, and composition of NPs by transmission electron microscopy (TEM) and energy-dispersive X-ray spectrometry (EDX) in 10 subjects from Metropolitan Mexico City (MMC) with a mean age of 25.3 +/- 5.9 and a 71-year-old subject without cardiac pathology. We found that in every case, Fe, Ti, Al, Hg, Cu, Bi, and/or Si spherical or acicular NPs with a mean size of 36 +/- 17 nm were present in the AV axis in situ, freely and as conglomerates, within the mitochondria, sarcomeres, lysosomes, lipofuscin, and/or intercalated disks and gap junctions of Purkinje and transitional cells, telocytes, macrophages, endothelium, and adjacent atrial and ventricular fibers. Erythrocytes were found to transfer NPs to the endothelium. Purkinje fibers with increased lysosomal activity and totally disordered myofilaments and fragmented Z-disks exhibited NP conglomerates in association with gap junctions and intercalated disks. AV conduction axis pathology caused by environmental NPs is a plausible and modifiable risk factor for understanding common arrhythmias and reentrant tachycardia. Anthropogenic, industrial, e-waste, and indoor NPs reach pacemaker regions, thereby increasing potential mechanisms that disrupt the electrical impulse pathways of the heart. The cardiotoxic, oxidative, and abnormal electric performance effects of NPs in pacemaker locations warrant extensive research. Cardiac arrhythmias associated with nanoparticle effects could be preventable.

引用

页码：8203 / 8214

页数：12

共 68 条

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