The CCR5 and CXCR4 coreceptors - Central to understanding the transmission and pathogenesis of human immunodeficiency virus type 1 infection

被引：349
作者：
Moore, JP
Kitchen, SG
Pugach, P
Zack, JA
机构：
[1] Cornell Univ, Weill Med Coll, Dept Microbiol & Immunol, New York, NY 10021 USA
[2] Univ Calif Los Angeles, David Geffen Sch Med, UCLA AIDS Inst, Dept Med, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, David Geffen Sch Med, UCLA AIDS Inst, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA
来源：
AIDS RESEARCH AND HUMAN RETROVIRUSES | 2004年 / 20卷 / 01期
关键词：
D O I：
10.1089/088922204322749567
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In this review, we will discuss what is known, what is suspected, and what still remains obscure about the central role played by coreceptor expression and usage in the transmission and pathogenic consequences of human immunodeficiency virus type 1 (HIV-1) infection. An emphasis will be on the HIV-1 phenotypic variants that are defined by their usage of the CCR5 or CXCR4 coreceptors, and how the different cellular tropism of these variants influences how and where HIV-1 replicates in vivo. We will also review what might happen when coreceptor antagonists are used clinically to treat HIV-1 infection.
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页码：111 / 126
页数：16
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