Photoacoustic Imaging Probes Based on Tetrapyrroles and Related Compounds

被引:16
作者
Merkes, Jean Michel [1 ]
Zhu, Leiming [1 ]
Bahukhandi, Srishti Ballabh [1 ]
Rueping, Magnus [1 ,2 ,3 ]
Kiessling, Fabian [3 ]
Banala, Srinivas [1 ,3 ]
机构
[1] Rhein Westfal TH Aachen, Inst Organ Chem, Landoltweg 1, D-52074 Aachen, Germany
[2] King Abdullah Univ Sci & Technol, KAUST Catalysis Ctr KCC, Thuwal 239556900, Saudi Arabia
[3] Univ Clin, RWTH Aachen, Inst Expt Mol Imaging, Forckenbeckstr 55, D-52074 Aachen, Germany
关键词
porphyrins; core-modified porphyrins; phthalocyanines; activatable probes; azacalixphyrin; near-infrared (NIR) dyes; NIR-II dyes; MULTISPECTRAL OPTOACOUSTIC TOMOGRAPHY; SENSITIZED SOLAR-CELLS; ABSORBING PORPHYRIN DERIVATIVES; CONTRAST AGENTS; SHELL MICROBUBBLES; ULTRASOUND; THERAPY; NAPHTHALOCYANINES; PHTHALOCYANINES; NANOPARTICLES;
D O I
10.3390/ijms21093082
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Photoacoustic imaging (PAI) is a rapidly evolving field in molecular imaging that enables imaging in the depths of ultrasound and with the sensitivity of optical modalities. PAI bases on the photoexcitation of a chromophore, which converts the absorbed light into thermal energy, causing an acoustic pressure wave that can be captured with ultrasound transducers, in generating an image. For in vivo imaging, chromophores strongly absorbing in the near-infrared range (NIR; > 680 nm) are required. As tetrapyrroles have a long history in biomedical applications, novel tetrapyrroles and inspired mimics have been pursued as potentially suitable contrast agents for PAI. The goal of this review is to summarize the current state of the art in PAI applications using tetrapyrroles and related macrocycles inspired by it, highlighting those compounds exhibiting strong NIR-absorption. Furthermore, we discuss the current developments of other absorbers for in vivo photoacoustic (PA) applications.
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页数:20
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