Plasticity of Mitochondrial DNA Inheritance and Its Impact on Nuclear Gene Transcription in Yeast Hybrids

被引:15
作者
Hewitt, Sarah K. [1 ,2 ]
Duangrattanalert, Kobchai [1 ,2 ]
Burgis, Tim [2 ]
Zeef, Leo A. H. [2 ]
Naseeb, Samina [1 ,2 ]
Delneri, Daniela [1 ,2 ]
机构
[1] Univ Manchester, Fac Biol Med & Hlth, Manchester Inst Biotechnol, Manchester M1 7DN, Lancs, England
[2] Univ Manchester, Fac Biol Med & Hlth, Div Evolut & Genom Sci, Manchester M13 9PL, Lancs, England
基金
欧盟地平线“2020”; 英国生物技术与生命科学研究理事会;
关键词
nuclear transcription; hybrids yeast; mitochondria; SACCHAROMYCES-CEREVISIAE; NATURAL HYBRIDS; EXPRESSION; EVOLUTION; KUDRIAVZEVII; GENOMES; WINE;
D O I
10.3390/microorganisms8040494
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Mitochondrial DNA (mtDNA) in yeast is biparentally inherited, but colonies rapidly lose one type of parental mtDNA, thus becoming homoplasmic. Therefore, hybrids between the yeast species possess two homologous nuclear genomes, but only one type of mitochondrial DNA. We hypothesise that the choice of mtDNA retention is influenced by its contribution to hybrid fitness in different environments, and the allelic expression of the two nuclear sub-genomes is affected by the presence of different mtDNAs in hybrids. Saccharomyces cerevisiae/S. uvarum hybrids preferentially retained S. uvarum mtDNA when formed on rich media at colder temperatures, while S. cerevisiae mtDNA was primarily retained on non-fermentable carbon source, at any temperature. Transcriptome data for hybrids harbouring different mtDNA showed a strong environmentally dependent allele preference, which was more important in respiratory conditions. Co-expression analysis for specific biological functions revealed a clear pattern of concerted allelic transcription within the same allele type, which supports the notion that the hybrid cell works preferentially with one set of parental alleles (or the other) for different cellular functions. Given that the type of mtDNA retained in hybrids affects both nuclear expression and fitness, it might play a role in driving hybrid genome evolution in terms of gene retention and loss.
引用
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页数:15
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