Ag doped ZnO nanorods catalyzed photo -triggered synthesis of some novel (1H-tetrazol-5-yl)-coumarin hybrids

被引：25
作者：
Attia, Yasser A. [1 ]
Mohamed, Yasser M. A. [2 ]
Awad, Mohamed M. [3 ]
Alexeree, Shaimaa [1 ]
机构：
[1] Cairo Univ, Natl Inst Laser Enhanced Sci, Giza 12613, Egypt
[2] Natl Res Ctr, Photochem Dept, Giza 12622, Egypt
[3] Loughborough Univ, Phys Dept, Loughborough LE11 3TU, Leics, England
来源：
JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2020年 / 919卷
关键词：
ENHANCED PHOTOCATALYTIC DEGRADATION; 5-SUBSTITUTED; 1H-TETRAZOLES; ANTICANCER AGENTS; 3+2 CYCLOADDITION; HIGHLY EFFICIENT; NANOPARTICLES; TETRAZOLE; NITRILES; ACID; ANTIBACTERIAL;
D O I：
10.1016/j.jorganchem.2020.121320
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Herein, we reported a facile synthetic strategy for the synthesis of 1,5-disubstituted tetrazole (1,5-DST) based chromone derivatives with different through photocatalyzed one-pot multicomponent reactions between aldehyde derivatives 7a-c, sodium azide, chromenocyl bromide in presence of triethylamine using ZnO nanorods (NRs) and Ag-doped ZnO nanocomposites (NCs) as photocatalysts. The reaction optimization was developed under ambient conditions at room temperature in dark and under visible light irradiation which revealed that Ag/ZnO NCs showed efficient catalytic activity towards the synthesis of new 1,5-DST through photocatalytic [3 + 2] cycloaddition reaction. The products 10a-f were afforded in excellent yields (90%–97%). The as-prepared tetrazole derivatives were subjected under cytotoxic evaluation towards MCF-7, HepG2, A549 and Wi38 cancer cell lines. It was revealed that compounds 10e and 10f showed potent anticancer activity. © 2020 Elsevier B.V.
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页数：8
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