Prader-Willi syndrome and psychotic symptoms: 1. Case descriptions and genetic studies

被引：32

作者：

Clarke, D

Boer, H

Webb, T

Scott, P

Frazer, S

Vogels, A

Borghgraef, M

Curfs, LMG

机构：

[1] Univ Birmingham, Dept Psychiat, Birmingham, W Midlands, England

[2] Birmingham Matern Hosp, Dept Clin Genet, Birmingham, W Midlands, England

[3] Univ Ziekenhuizen, Ctr Menselijke Erfelijkheid, Louvain, Belgium

[4] Clin Genet Ctr, Maastricht, Netherlands

来源：

JOURNAL OF INTELLECTUAL DISABILITY RESEARCH | 1998年 / 42卷

关键词：

chromosomes; human genetics; psychoses;

D O I：

10.1046/j.1365-2788.1998.4260440.x

中图分类号：

G76 [特殊教育];

学科分类号：

040109 ;

摘要：

Six people with Prader-Willi syndrome (PWS) who developed psychoses are described. Along with other literature reviewed in the present paper, the results imply an association between PWS and psychotic symptoms. Genetic studies were possible in five cases and SNRPN expression was examined in three cases. Maternal uniparental disomy and 15q11q13 deletions were found, demonstrating that psychotic symptoms are not associated with a single type of genetic abnormality.

引用

页码：440 / 450

页数：11