Protective Effect of Pycnogenol® on Ovariectomy-induced Bone Loss in Rats

被引:6
|
作者
Mei, Lin [2 ]
Mochizuki, Miyako [3 ]
Hasegawa, Noboru [1 ]
机构
[1] Ishikawa Prefectural Nursing Univ, Dept Hlth & Med Sci, Kahoku, Ishikawa 9291212, Japan
[2] Gifu Womens Univ, Gifu 5012592, Japan
[3] Higashiosaka Jr Coll, Higashiosaka, Osaka 5778567, Japan
关键词
Pycnogenol (R); multiparous ovariectomized rat; bone strength; bone mineral density; osteocalcin; C-terminal telopeptide of type I collagen; POSTMENOPAUSAL WOMEN; OXIDATIVE STRESS; MINERAL DENSITY; TURNOVER; VITAMIN; TRIAL;
D O I
10.1002/ptr.3541
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Pycnogenol (R) (PYC) is a natural plant extract from the bark of Pinus pinaster and has potent antioxidant activities. The protective effect of PYC on bone loss was studied in multiparous ovariectomized (OVX) female rats. Pycnogenol (R) (30 or 15 mg/kg body weight/day) was administered orally to 8-month-old OVX rats for 3 months. At the end of the experiment, bone strength was measured by a three-point bending test and bone mineral density was estimated by peripheral quantitative computed tomography. Ovariectomy significantly decreased femur bone strength and bone density. Supplementation with PYC suppressed the bone loss induced by OVX. The OVX treatment significantly increased serum osteocalcin (OC) and C-terminal telopeptide of type I collagen (CTx). Supplementation with PYC reduced the serum OC and CTx in OVX rats to a level similar to that of the sham-operated group. The results indicated that orally administered PYC can decrease the bone turnover rate in OVX rats, resulting in positive effects on the biomechanical strength of bone and bone mineral density. Copyright (C) 2011 John Wiley & Sons, Ltd.
引用
收藏
页码:153 / 155
页数:3
相关论文
共 50 条
  • [31] Methanolic Extract of Cuminum cyminum Inhibits Ovariectomy-Induced Bone Loss in Rats
    Shirke, Sarika S.
    Jadhav, Sanket R.
    Jagtap, Aarti G.
    EXPERIMENTAL BIOLOGY AND MEDICINE, 2008, 233 (11) : 1403 - 1410
  • [32] EFFECTS OF EXERCISE AND CALCIUM SUPPLEMENTATION IN THE PREVENTION OF OVARIECTOMY-INDUCED BONE LOSS IN RATS
    GALA, J
    CURIEL, MD
    DELAPIEDRA, C
    CASTILLA, C
    RAPADO, A
    JOURNAL OF BONE AND MINERAL RESEARCH, 1995, 10 : S450 - S450
  • [33] The Effect of Vitamin K and D Supplementation on Ovariectomy-Induced Bone Loss
    S. Matsunaga
    H. Ito
    T. Sakou
    Calcified Tissue International, 1999, 65 : 285 - 289
  • [34] Vitamin K supplementation ovariectomy-induced bone does not affect loss in rats
    Binkley, N
    Krueger, D
    Engelke, J
    Crenshaw, T
    Suttie, J
    BONE, 2002, 30 (06) : 897 - 900
  • [35] Cannabidiol does not ameliorate ovariectomy-induced bone loss in skeletally mature rats
    Chanpaisaeng, Krittikan
    Phonsatta, Nathaporn
    Panya, Atikorn
    Charoenphandhu, Narattaphol
    JOURNAL OF BONE AND MINERAL RESEARCH, 2024, 39 : 251 - 251
  • [36] Nano-Calcium Ameliorates Ovariectomy-Induced Bone Loss in Female Rats
    Choi, Hyeon-Son
    Han, JeungHi
    Chung, Seungsik
    Hong, Yang Hee
    Suh, Hyung Joo
    KOREAN JOURNAL FOR FOOD SCIENCE OF ANIMAL RESOURCES, 2013, 33 (04) : 515 - 521
  • [37] Biglycan deficiency interferes with ovariectomy-induced bone loss
    Nielsen, KL
    Allen, MR
    Bloomfield, SA
    Andersen, TL
    Chen, XD
    Poulsen, HS
    Young, MF
    Heegaard, AM
    JOURNAL OF BONE AND MINERAL RESEARCH, 2003, 18 (12) : 2152 - 2158
  • [38] Protection against Ovariectomy-Induced Bone Loss by Tranilast
    Tien Van Phan
    Ke, Ke
    Sul, Ok-Joo
    Park, Yun-Kyung
    Kim, Kack-Kyun
    Cho, Yeon-Soo
    Chung, Hun-Taeg
    Choi, Hye-Seon
    PLOS ONE, 2014, 9 (04):
  • [39] PREVENTION OF OVARIECTOMY-INDUCED BONE LOSS IN MICE BY BORTEZOMIB
    Lee, Y.
    OSTEOPOROSIS INTERNATIONAL, 2017, 28 : S412 - S412
  • [40] A bone-protective role for IL-17 receptor signaling in ovariectomy-induced bone loss
    Goswami, Jaya
    Hernandez-Santos, Nydiaris
    Zuniga, Luis A.
    Gaffen, Sarah L.
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2009, 39 (10) : 2831 - 2839