Synthetic biology-based optogenetic approaches to control therapeutic designer cells

被引：6
|
作者：
Mansouri, Maysam [1 ]
Fussenegger, Martin [1 ,2 ]
机构：
[1] Swiss Fed Inst Technol, Dept Biosyst Sci & Engn, Mattenstr 26, CH-4058 Basel, Switzerland
[2] Univ Basel, Fac Sci, Mattenstr 26, CH-4058 Basel, Switzerland
来源：
CURRENT OPINION IN SYSTEMS BIOLOGY | 2021年 / 28卷
基金：
欧洲研究理事会; 欧盟地平线“2020”;
关键词：
Synthetic biology; Optogenetics; Therapeutic cell engineering; Cell-based therapy; Gene therapy; Remote-controllable genetic circuits; LIGHT; GENE; ACTIVATION; SYSTEMS;
D O I：
10.1016/j.coisb.2021.100396
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Optogenetics uses light as a traceless inducer to remotely control cellular behavior with high safety and spatiotemporal precision, and its implementation for therapeutic synthetic biology enable customizable user-defined remedial outputs to be generated from suitably engineered cells. Here, we focus on non-neural optogenetics, describing the tools and strategies available to engineer light-responsive, therapeutic mammalian designer cells and highlighting recent advances in design and translational applications, including cell and gene therapies. We also discuss current limitations in engineering genetically encoded light-sensitive systems and suggest some possible solutions.
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页数：8
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