Synthetic biology-based optogenetic approaches to control therapeutic designer cells

被引：9

作者：

Mansouri, Maysam ^{[1
]}

Fussenegger, Martin ^{[1
,2
]}

机构：

[1] Swiss Fed Inst Technol, Dept Biosyst Sci & Engn, Mattenstr 26, CH-4058 Basel, Switzerland

[2] Univ Basel, Fac Sci, Mattenstr 26, CH-4058 Basel, Switzerland

来源：

CURRENT OPINION IN SYSTEMS BIOLOGY | 2021年 / 28卷

基金：

欧盟地平线“2020”; 欧洲研究理事会;

关键词：

Synthetic biology; Optogenetics; Therapeutic cell engineering; Cell-based therapy; Gene therapy; Remote-controllable genetic circuits; LIGHT; GENE; ACTIVATION; SYSTEMS;

D O I：

10.1016/j.coisb.2021.100396

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Optogenetics uses light as a traceless inducer to remotely control cellular behavior with high safety and spatiotemporal precision, and its implementation for therapeutic synthetic biology enable customizable user-defined remedial outputs to be generated from suitably engineered cells. Here, we focus on non-neural optogenetics, describing the tools and strategies available to engineer light-responsive, therapeutic mammalian designer cells and highlighting recent advances in design and translational applications, including cell and gene therapies. We also discuss current limitations in engineering genetically encoded light-sensitive systems and suggest some possible solutions.

引用

页数：8

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