IL28B polymorphism and the control of hepatitis C virus infection : ready for clinical use ?

被引：0

作者：

Orlent, Hans ^{[1
]}

Reynaert, Hendrik ^{[2
]}

Bourgeois, Stefan ^{[3
]}

Dideberg, Vinciane ^{[4
]}

Adler, Michael ^{[5
]}

Colle, Isabelle ^{[6
]}

De Maeght, Stephane ^{[7
]}

Laleman, Wim ^{[8
]}

Michielsen, Peter ^{[9
]}

Moreno, Christophe ^{[5
]}

Mulkay, Jean-Pierre ^{[10
]}

Starkel, Peter ^{[11
]}

Delwaide, Jean ^{[12
]}

机构：

[1] Acad Hosp St Jan, Dept Gastroenterol & Hepatol, Brugge, Belgium

[2] UZ Brussel, Dept Gastroenterol, Brussels, Belgium

[3] AZ Stuivenberg, Dept Gastroenterol, Antwerp, Belgium

[4] Univ Liege, CHU Sart Tilman, Dept Genet, Liege, Belgium

[5] Univ Libre Bruxelles, Erasme Hosp, Dept Gastroenterol & Hepatopancreatol, Brussels, Belgium

[6] Ghent Univ Hosp, Dept Gastroenterol & Hepatol, B-9000 Ghent, Belgium

[7] Hop Jolimont, Serv Hepatogastroenterol, Haine St Paul, Belgium

[8] Catholic Univ Louvain, Univ Hosp Gasthuisberg, Dept Hepatol, B-3000 Louvain, Belgium

[9] Univ Antwerp Hosp, Div Hepatogastroenterol, Antwerp, Belgium

[10] CHU St Pierre, Dept Hepatogastroenterol, Brussels, Belgium

[11] Clin Univ St Luc UCL, Serv Hepatol, Woluwe St Lambert, Belgium

[12] Univ Liege, CHU Sart Tilman, Dept Gastroenterol, Liege, Belgium

来源：

ACTA GASTRO-ENTEROLOGICA BELGICA | 2011年 / 74卷 / 02期

关键词：

GENETIC-VARIATION; SPONTANEOUS CLEARANCE; INTERFERON-LAMBDA; INTERLEUKIN; 28B; VIRAL RESPONSE; CORE REGION; GENOTYPE; THERAPY; PEGINTERFERON; CHOLESTEROL;

D O I：

暂无

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Polymorphisms in the region of the interleukin-28B (IL28B) gene have recently been associated with spontaneous and treatment induced clearance of hepatitis C virus infection. The specific mechanisms of how IL28B polymorphisms affect HCV suppression remain unknown. It is a matter of ongoing debate how to incorporate the IL28B data into the current treatment algorithms with pegylated interferon-alpha and ribavirin. The eventual role of the IL28B genotype in new therapeutic regimes with direct antiviral agents needs to be explored in the ongoing and future clinical studies with these agents. (Acta gastroenterol. belg., 2011, 74, 317-322).

引用

页码：317 / 322

页数：6

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