Cyclodextrins 3-Functionalized with 8-Hydroxyquinolines: Copper-Binding Ability and Inhibition of Synuclein Aggregation

被引：16
作者：
Oliveri, Valentina [1 ,2 ]
Sgarlata, Carmelo [1 ]
Vecchio, Graziella [1 ]
机构：
[1] Univ Catania, Dipartimento Sci Chim, Viale A Doria 6, I-95125 Catania, Italy
[2] CIRCMSB, Unita Ric Catania, I-95125 Catania, Italy
来源：
CHEMISTRY-AN ASIAN JOURNAL | 2016年 / 11卷 / 17期
关键词：
chelates; copper; glycoconjugates; inhibitors; metal complexes; ALPHA-SYNUCLEIN; BETA-CYCLODEXTRIN; OXIDATIVE STRESS; OLIGOMERS; COMPLEXES; CHEMISTRY; CURCUMIN; LIGANDS;
D O I：
10.1002/asia.201600824
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Neurodegenerative diseases such as Parkinson's and Alzheimer's diseases are multifactorial disorders related to protein aggregation, metal dyshomeostasis, and oxidative stress. To advance understanding in this area and to contribute to therapeutic development, many efforts have been directed at devising suitable agents that can target metal ions associated with relevant biomolecules such as -synuclein. This paper presents a new cyclodextrin-8-hydroxyquinoline conjugate and discusses the properties of four cyclodextrins 3-functionalized with 8-hydroxyquinoline as copper(II) chelators and inhibitors of copper-induced synuclein aggregation. The encouraging results establish the potential of cyclodextrin-8-hydroxyquinoline conjugates as chelators for the control of copper toxicity.
引用
收藏
页码：2436 / 2442
页数：7
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