Recent Advances in siRNA Delivery Systems for Prostate Cancer Therapy

被引：9
作者：
Aghamiri, Shahin [1 ,2 ]
Raee, Pourya [3 ]
Shahmohamadnejad, Shiva [4 ]
Shabani, Sasan [5 ]
Ghorbani, Jaber [6 ]
Sameni, Marzieh [7 ]
Ebrahimi, Mohammad Taha [7 ]
机构：
[1] Shahid Beheshti Univ Med Sci, Sch Adv Technol Med, Dept Med Biotechnol, Tehran 193954818, Iran
[2] Shahid Beheshti Univ Med Sci, Cellular & Mol Biol Res Ctr, Tehran, Iran
[3] Shahid Beheshti Univ Med Sci, Sch Med, Dept Biol & Anat Sci, Tehran, Iran
[4] Univ Tehran Med Sci, Dept Biochem, Fac Med, Tehran, Iran
[5] Univ Tehran Med Sci, Sch Med, Dept Med Genet, Tehran, Iran
[6] Univ Tehran Med Sci, Sch Med, Dept Microbiol, Tehran, Iran
[7] Shahid Beheshti Univ Med Sci, Dept Med Biotechnol, Sch Adv Technol Med, Tehran, Iran
来源：
CURRENT PHARMACEUTICAL BIOTECHNOLOGY | 2022年 / 23卷 / 04期
关键词：
Prostate cancer; nanoparticles; siRNA; drug delivery systems; multidrug resistance; combination therapy; CELL-ADHESION MOLECULE; SMALL INTERFERING RNA; MULTIDRUG-RESISTANCE; CO-DELIVERY; DRUG-DELIVERY; ANTISENSE OLIGONUCLEOTIDE; TARGETED DELIVERY; CATIONIC NANOBUBBLES; ANTICANCER DRUGS; PHASE-I;
D O I：
10.2174/1389201022666210615123211
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The critical problems of conventional prostate cancer therapeutic strategies like nonspecific toxicity and multi-drug resistance prompted the development and application of countless nanoparticle-based siRNA therapeutics. Unfortunately, siRNA-based therapeutics suffer from the lack of safe and effective delivery systems, immune system stimulation, poor knowledge of nano-bio interactions, and limitations concerning designing, manufacturing, clinical translation, and commercialization. In this review, we provide cutting-edge advances in nanoparticle-mediated siRNA delivery carriers like polymeric systems, lipid systems, specific systems, and rigid nanoparticles for the treatment of prostate cancer. Moreover, co-delivery of conventional chemotherapy drugs with siRNA as a revolutionary robust strategy for prostate cancer combinational therapy is completely covered.
引用
收藏
页码：579 / 593
页数：15
相关论文
共 129 条
  • [1] Bcl-2-regulated apoptosis: mechanism and therapeutic potential
    Adams, Jerry M.
    Cory, Suzanne
    [J]. CURRENT OPINION IN IMMUNOLOGY, 2007, 19 (05) : 488 - 496
  • [2] Chitosan (CMD)-mediated co-delivery of SN38 and Snail-specific siRNA as a useful anticancer approach against prostate cancer
    Afkham, Amir
    Aghebati-Maleki, Leili
    Siahmansouri, Homayoon
    Sadreddini, Sanam
    Ahmadi, Majid
    Dolati, Sanam
    Afkham, Nahid Manafi
    Akbarzadeh, Parvin
    Jadidi-Niaragh, Farhad
    Younesi, Vahid
    Yousefi, Mehdi
    [J]. PHARMACOLOGICAL REPORTS, 2018, 70 (03) : 418 - 425
  • [3] Photoregulated Release of Caged Anticancer Drugs from Gold Nanoparticles
    Agasti, Sarit S.
    Chompoosor, Apiwat
    You, Chang-Cheng
    Ghosh, Partha
    Kim, Chae Kyu
    Rotello, Vincent M.
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (16) : 5728 - +
  • [4] Everyday discrimination and telomere length in a multiethnic cohort of breast cancer survivors
    Aghaee, Sara
    Allen, Amani
    Ramirez, Julio
    Shariff-Marco, Salma
    Allen, Laura
    DeRouen, Mindy
    Elmofty, May
    Marquez-Magana, Leticia
    Gomez, Scarlett Lin
    [J]. ETHNICITY & HEALTH, 2022, 27 (03) : 542 - 553
  • [5] Nanoparticles-mediated CRISPR/Cas9 delivery: Recent advances in cancer treatment
    Aghamiri, Shahin
    Talaei, Sam
    Ghavidel, Afshin Abdi
    Zandsalimi, Farshid
    Masoumi, Saeid
    Hafshejani, Nahid Heidari
    Jajarmi, Vahid
    [J]. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2020, 56
  • [6] Nanoparticle-siRNA: a potential strategy for ovarian cancer therapy?
    Aghamiri, Shahin
    Mehrjardi, Keyvan Fallah
    Shabani, Sasan
    Keshavarz-Fathi, Mahsa
    Kargar, Saeed
    Rezaei, Nima
    [J]. NANOMEDICINE, 2019, 14 (15) : 2083 - 2100
  • [7] siRNA nanotherapeutics: a promising strategy for anti-HBV therapy
    Aghamiri, Shahin
    Jafarpour, Ali
    Gomari, Mohammad Mahmoudi
    Ghorbani, Jaber
    Rajabibazl, Masoumeh
    Payandeh, Zahra
    [J]. IET NANOBIOTECHNOLOGY, 2019, 13 (05) : 457 - 463
  • [8] Effect of resveratrol on the radiosensitivity of 5-FU in human breast cancer MCF-7 cells
    Aghamiri, Shahin
    Jafarpour, Ali
    Zandsalimi, Farshid
    Aghemiri, Mehran
    Shoja, Mohsen
    [J]. JOURNAL OF CELLULAR BIOCHEMISTRY, 2019, 120 (09) : 15671 - 15677
  • [9] Targeting siRNA in colorectal cancer therapy: Nanotechnology comes into view
    Aghamiri, Shahin
    Jafarpour, Ali
    Malekshahi, Ziba Veisi
    Gomari, Mohammad Mahmoudi
    Negahdari, Babak
    [J]. JOURNAL OF CELLULAR PHYSIOLOGY, 2019, 234 (09) : 14818 - 14827
  • [10] Application of Chitosan in Bone and Dental Engineering
    Aguilar, Alicia
    Zein, Naimah
    Harmouch, Ezeddine
    Hafdi, Brahim
    Bornert, Fabien
    Offner, Damien
    Clauss, Francois
    Fioretti, Florence
    Huck, Olivier
    Benkirane-Jessel, Nadia
    Hua, Guoqiang
    [J]. MOLECULES, 2019, 24 (16):
12345678910