Expression of Fgf and Tgfβ signaling related genes during embryonic endochondral ossification

被引：48

作者：

Minina, E

Schneider, S

Rosowski, M

Lauster, R

Vortkamp, A

机构：

[1] Max Planck Inst Mol Genet, Otto Warburg Lab, D-14195 Berlin, Germany

[2] Deutsches Rheuma Forschungszentrum, D-10117 Berlin, Germany

[3] GSF, Natl Res Ctr Environm & Hlth, Inst Dev Genet, D-85764 Neuherberg, Germany

[4] Univ Essen Gesamthsch, Ctr Med Biotechnol, Dept Dev Biol 1, D-45117 Essen, Germany

来源：

GENE EXPRESSION PATTERNS | 2005年 / 6卷 / 01期

关键词：

endochondral ossification; chondrocyte differentiation; Ihh; Pthr; Bmp2; Bmp3; Bmp4; Bmp6; Bmp7; noggin; follistatin; Inh beta a; activin; Tgf beta 1; Tgf beta 2; Tgf beta 3; Bmpr1a; Bmpr1b; Bmpr2; Acvr11; Acvr1; Acvr1b; Acvr2; Tgf beta r1; Smad1; Smad3; Smad5; Fgf2; Fgf8; FGF12; Fgf18; Fgfr1; Fgfr2; Fgfr3; Fgfr4;

D O I：

10.1016/j.modgep.2005.04.012

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Disturbed fibroblast growth factor (Fgf) and transforming growth factor beta (Tgf beta) signaling lead to a variety of human skeletal disorders. To reveal the possible function and interaction of these signaling systems we have started to analyze the expression patterns of signaling factors, antagonists, receptors and transducers of these pathways in forelimbs of mouse embryos and compared them to the expression of established markers including Ihh. In addition to defining their expression domains in the developing bone, our study identified new subpopulations of chondrocytes characterized by the expression of distinct combinations of markers. (c) 2005 Elsevier B.V. All rights reserved.

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页码：102 / 109

页数：8

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