Alzheimer's disease hypothesis and related therapies

被引：431

作者：

Du, Xiaoguang ^{[1
]}

Wang, Xinyi ^{[1
]}

Geng, Meiyu ^{[2
]}

机构：

[1] Shanghai GreenValley Pharmaceut Co Ltd, 421 Newton Rd, Shanghai 201203, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China

来源：

TRANSLATIONAL NEURODEGENERATION | 2018年 / 7卷

关键词：

Alzheimer's disease; complicated disease; anti-AD drugs; Hypothesis about AD; AMYLOID-BETA-PEPTIDE; GAMMA-SECRETASE; VAGUS NERVE; PRECURSOR PROTEIN; OXIDATIVE STRESS; TREM2; VARIANTS; DOUBLE-BLIND; CHOLINERGIC MODULATION; CORTICAL ACETYLCHOLINE; COGNITIVE IMPAIRMENT;

D O I：

10.1186/s40035-018-0107-y

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause for dementia. There are many hypotheses about AD, including abnormal deposit of amyloid beta (A beta) protein in the extracellular spaces of neurons, formation of twisted fibers of tau proteins inside neurons, cholinergic neuron damage, inflammation, oxidative stress, etc., and many anti-AD drugs based on these hypotheses have been developed. In this review, we will discuss the existing and emerging hypothesis and related therapies.

引用

页数：7

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