FGF-16 is required for embryonic heart development

被引：54

作者：

Lu, Shun Yan ^{[1
]}

Sheikh, Farah ^{[2
]}

Sheppard, Patricia C. ^{[1
]}

Fresnoza, Agnes ^{[1
]}

Duckworth, Mary Lynn ^{[1
]}

Detillieux, Karen A. ^{[1
]}

Cattini, Peter A. ^{[1
]}

机构：

[1] Univ Manitoba, Dept Phys, Winnipeg, MB R3E 3J7, Canada

[2] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2008年 / 373卷 / 02期

关键词：

fibroblast growth factor; heart; myocardial defect; mouse; mid-gestation;

D O I：

10.1016/j.bbrc.2008.06.029

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fibroblast growth factor 16 (FGF-16) expression has previously been detected in mouse heart at mid-gestation in the endocardium and epicardium, suggesting a role in embryonic heart development. More specifically, exogenously applied FGF-16 has been shown to stimulate growth of embryonic myocardial cells in tissue explants. We have generated mice lacking FGF-16 by targeting the Fgf16 locus on the X chromosome. Elimination of Fgf16 expression resulted in embryonic death as early as day 11.5 (E11.5). External abnormalities, including hemorrhage in the heart and ventral body region as well as facial defects, began to appear in null embryos from E11.5. Morphological analysis of FGF-16 null hearts revealed cardiac defects including chamber dilation, thinning of the atrial and ventricular walls, and poor trabeculation, which were visible at E10.5 and more pronounced at E11.5. These findings indicate FGF-16 is required for embryonic heart development in mid-gestation through its positive effect on myocardial growth. (C) 2008 Elsevier Inc. All rights reserved

引用

页码：270 / 274

页数：5

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