The DNA methylation status of genes encoding Matrix metalloproteinases and tissue inhibitors of Matrix metalloproteinases in endometriosis

被引：16
作者：
Tang, Longying [1 ]
Xiang, Yuqian [2 ,3 ]
Zhou, Yaohua [4 ]
Mu, Jian [2 ]
Zai, Meiqing [2 ]
Xing, Qinghe [2 ]
Zhao, Xinzhi [2 ]
He, Lin [2 ,5 ]
Wang, Lei [6 ,7 ,8 ]
Dong, Xi [9 ]
Li, Qiaoli [2 ,6 ,7 ]
机构：
[1] Shanghai Changning Matern & Infant Hlth Hosp, Shanghai, Peoples R China
[2] Fudan Univ, Inst Biomed Sci, Shanghai 200032, Peoples R China
[3] Shanghai Jiao Tong Univ, Int Peace Matern & Child Hlth Hosp, Inst Embryofetal Original Adult Dis, Sch Med,Shanghai Key Lab Reprod Med, Shanghai, Peoples R China
[4] Shanghai Jiao Tong Univ, Tong Ren Hosp, Sch Med, Shanghai, Peoples R China
[5] Shanghai Jiao Tong Univ, Biox Ctr, Key Lab Genet Dev & Neuropsychiat Disorders, Minist Educ, Shanghai, Peoples R China
[6] Fudan Univ, Sch Life Sci, State Key Lab Genet Engn, Shanghai 200032, Peoples R China
[7] Fudan Univ, Sch Life Sci, MOE Key Lab Contemporary Anthropol, Shanghai 200032, Peoples R China
[8] Guangzhou Med Univ, Guangzhou Med Univ & Guangzhou Inst Biomed & Hlth, Guangzhou, Guangdong, Peoples R China
[9] Fudan Univ, Zhongshan Hosp, Reprod Med Ctr, Shanghai 200032, Peoples R China
来源：
MOLECULAR REPRODUCTION AND DEVELOPMENT | 2018年 / 85卷 / 01期
基金：
中国国家自然科学基金;
关键词：
correlation; gene expression; promoter region; ECTOPIC ENDOMETRIUM; PROGESTERONE-RECEPTOR; EUTOPIC ENDOMETRIUM; EXPRESSION; CELLS; PATHOGENESIS; OVARIAN; MATRIX-METALLOPROTEINASE-9; DYSREGULATION; COLLAGENASE;
D O I：
10.1002/mrd.22931
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Endometriosis is a benign disease, with malignant properties. A necessary step in the progression of endometriosis is tissue remodeling, which is coordinated by the activities of matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs). This study evaluated the regulation of abnormal MMP and TIMP gene expression during endometriosis. Among the two genes families, promoter regions of MMP2, MMP3, MMP7, TIMP3, and TIMP4 were significantly altered in proliferative-phase endometriotic lesions compared to menstrual cycle-matched eutopic tissue from endometriosis-free women. In addition, a negative correlation was found between the DNA methylation status of the promoter region and transcript abundance of MMP2. Our findings suggest that changes in DNA methylation at the promoter region of MMP2 could underlie the changes in its expression in the ectopic endometria from patients with endometriosis.
引用
收藏
页码：17 / 25
页数：9
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