The gastric precancerous cascade

被引：606

作者：

Correa, Pelayo ^{[1
]}

Piazuelo, M. Blanca ^{[1
]}

机构：

[1] Vanderbilt Univ, Med Ctr, Dept Med, Div Gastroenterol, Nashville, TN 37232 USA

来源：

JOURNAL OF DIGESTIVE DISEASES | 2012年 / 13卷 / 01期

关键词：

dysplasia; gastric carcinoma; intestinal metaplasia; precancerous cascade; HELICOBACTER-PYLORI INFECTION; TERM-FOLLOW-UP; METAPLASIA TYPE-III; HIGH-RISK AREA; INTESTINAL METAPLASIA; HUMAN STOMACH; PRENEOPLASTIC LESIONS; CANCER-EPIDEMIOLOGY; ATROPHIC GASTRITIS; CARCINOGENESIS;

D O I：

10.1111/j.1751-2980.2011.00550.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Invasive gastric carcinoma is preceded by a cascade of precancerous lesions. The first recognized histologic change is active chronic inflammation, which may persist as such: non-atrophic chronic gastritis (no gland loss), or advance to multifocal atrophic gastritis (MAG), the first real step in the precancerous cascade. The following steps are: intestinal metaplasia (first complete and then incomplete); dysplasia, first low grade and then high grade (equivalent to carcinoma in situ). The following step is invasive carcinoma, which is thought to be associated with degradation of the intercellular matrix.

引用

页码：2 / 9

页数：8

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