COVID 19: a clue from innate immunity

被引：123

作者：

Birra, Domenico ^{[1
]}

Benucci, Maurizio ^{[2
]}

Landolfi, Luigi ^{[3
]}

Merchionda, Anna ^{[1
]}

Loi, Gabriella ^{[1
]}

Amato, Patrizia ^{[4
]}

Licata, Gaetano ^{[5
]}

Quartuccio, Luca ^{[6
]}

Triggiani, Massimo ^{[7
]}

Moscato, Paolo ^{[1
]}

机构：

[1] Azienda Osped Univ San Giovanni di Dio & Ruggi DA, UOC Internal Med, Rheumatol Outpatients Unit, Via San Leonardo 1, Salerno, Italy

[2] S Giovanni di Dio Hosp, Rheumatol Unit, Florence, Italy

[3] Azienda Osped Univ San Giovanni di Dio & Ruggi DA, UOC Internal Med, Salerno, Italy

[4] ASL Salerno, SERT, Salerno, Italy

[5] Univ Campania Luigi Vanvitelli, Dermatol Unit, Naples, Italy

[6] Univ Udine, Dept Med DAME, ASUFC, Clin Rheumatol, Udine, Italy

[7] Univ Salerno, Div Allergy & Clin Immunol, Fisciano, Italy

来源：

IMMUNOLOGIC RESEARCH | 2020年 / 68卷 / 03期

关键词：

COVID-19; Coronavirus; SARS; Innate immunity; TLR; Interferon; ACUTE RESPIRATORY SYNDROME; TOLL-LIKE RECEPTORS; CORONAVIRUS INFECTION; I INTERFERON; SARS; PROTECTION; RESPONSES; DISEASE; TRIF;

D O I：

10.1007/s12026-020-09137-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The recent COVID-19 pandemic has had a significant impact on our lives and has rapidly expanded to reach more than 4 million cases worldwide by May 2020. These cases are characterized by extreme variability, from a mild or asymptomatic form lasting for a few days up to severe forms of interstitial pneumonia that may require ventilatory therapy and can lead to patient death. Several hypotheses have been drawn up to understand the role of the interaction between the infectious agent and the immune system in the development of the disease and the most severe forms; the role of the cytokine storm seems important. Innate immunity, as one of the first elements of guest interaction with different infectious agents, could play an important role in the development of the cytokine storm and be responsible for boosting more severe forms. Therefore, it seems important to study also this important arm of the immune system to adequately understand the pathogenesis of the disease. Research on this topic is also needed to develop therapeutic strategies for treatment of this disease.

引用

页码：161 / 168

页数：8

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