Au-Catalyzed Addition of Nucleophiles to Chloroalkynes: A Regio- and Stereoselective Synthesis of (Z)-Alkenyl Chlorides

被引：15

作者：

Liu, Congrong ^{[1
]}

Xue, Yunbo ^{[1
]}

Ding, Lianghui ^{[1
]}

Zhang, Haiyun ^{[1
]}

Yang, Fulai ^{[2
]}

机构：

[1] Nanjing Inst Technol, Sch Environm Engn, 1 Hongjingdadao, Nanjing 211167, Jiangsu, Peoples R China

[2] China Pharmaceut Univ, Dept State Key Lab Nat Med, Dept Organ Chem, Nanjing 210009, Jiangsu, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 2018卷 / 46期

基金：

中国国家自然科学基金;

关键词：

Alkenyl chlorides; Alkynes; Nucleophiles; Gold; Homogeneous catalysis; Addition reactions; CROSS-COUPLING REACTIONS; ONE-STEP SYNTHESIS; BORONIC ACIDS; TRISUBSTITUTED ALKENES; YNOL ETHERS; ALKYNES; HALOALKYNES; ACCESS; ALKYNYLATION; DERIVATIVES;

D O I：

10.1002/ejoc.201801222

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An unprecedented protocol has been developed for the regio- and stereoselective synthesis of (Z)-alkenyl chlorides via the gold-catalyzed addition of nucleophiles to chloroalkynes. In the presence of 1 mol-% BrettPhosAuCl, a broad range of nucleophiles smoothly react with aromatic, vinylic, or aliphatic chloroalkynes to afford various functionalized (Z)-alkenyl chlorides with high to excellent yields and extremely high stereoselectivity.

引用

页码：6537 / 6540

页数：4

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