Multiple ADH genes are associated with upper aerodigestive cancers

被引：144

作者：

Hashibe, Mia ^{[1
]}

Mckay, James D. ^{[1
]}

Curado, Maria Paula ^{[1
,2
,3
]}

Oliveira, Jose Carlos ^{[2
,3
]}

Koifman, Sergio ^{[4
]}

Koifman, Rosalina ^{[4
]}

Zaridze, David ^{[5
]}

Shangina, Oxana ^{[5
]}

Wuensch-Filho, Victor ^{[6
]}

Eluf-Neto, Jose ^{[6
]}

Levi, Jose Eduardo ^{[6
]}

Matos, Elena ^{[7
]}

Lagiou, Pagona

Lagiou, Areti ^{[8
]}

Benhamou, Simone ^{[8
,9
]}

Bouchardy, Christine ^{[10
]}

Szeszenia-Dabrowska, Neonilia ^{[11
]}

Menezes, Ana ^{[12
]}

Dall'Agnol, Marinel Mor ^{[12
]}

Merletti, Franco ^{[13
,14
]}

Richiardi, Lorenzo ^{[13
,14
]}

Fernandez, Leticia ^{[15
]}

Lence, Juan ^{[15
]}

Talamini, Renato ^{[16
]}

Barzan, Luigi ^{[17
]}

Mates, Dana ^{[18
]}

Mates, Ioan Nicolae ^{[19
]}

Kjaerheim, Kristina ^{[20
]}

Macfarlane, Gary J. ^{[21
]}

Macfarlane, Tatiana V. ^{[21
]}

Simonato, Lorenzo ^{[22
]}

Canova, Cristina ^{[22
]}

Holcatova, Ivana ^{[23
]}

Agudo, Antonio ^{[24
]}

Castellsague, Xavier ^{[24
]}

Lowry, Ray ^{[25
]}

Janout, Vladimir ^{[26
]}

Kollarova, Helena ^{[26
]}

Conway, David I. ^{[27
]}

McKinney, Patricia A. ^{[28
,29
]}

Znaor, Ariana ^{[30
]}

Fabianova, Eleonora ^{[31
]}

Bencko, Vladimir ^{[23
]}

Lissowska, Jolanta ^{[32
,33
]}

Chabrier, Amelie ^{[1
]}

Hung, Rayjean J. ^{[1
,34
]}

Gaborieau, Valerie ^{[1
]}

Boffetta, Paolo ^{[1
]}

Brennan, Paul ^{[1
]}

机构：

[1] Int Agcy Res Canc, F-69372 Lyon, France

[2] Hosp Araujo Jorge, Goiania, Go, Brazil

[3] Populat Canc Register Goiania, Goiania, Go, Brazil

[4] Escola Nacl Suade Publ, Rio De Janeiro, Brazil

[5] Russian Acad Med Sci, Canc Res Ctr, Moscow, Russia

[6] Univ Sao Paulo, Sao Paulo, Brazil

[7] Univ Buenos Aires, Inst Oncol Angel H Roffo, RA-1053 Buenos Aires, DF, Argentina

[8] Univ Athens, Sch Med, GR-11527 Athens, Greece

[9] Inst Natl Sante & Rech Med, U794, Evry, France

[10] Geneva Canc Registry, Geneva, Switzerland

[11] Inst Occupat Med, Lodz, Poland

[12] Univ Fed Pelotas, Pelotas, Brazil

[13] CeRMS, Canc Epidemiol Unit, Turin, Italy

[14] Univ Turin, Turin, Italy

[15] Inst Oncol & Radiobiol, Havana, Cuba

[16] Aviano Canc Ctr, I-33081 Aviano, Italy

[17] Gen Hosp, Pordenone, Italy

[18] Inst Publ Hlth, Bucharest, Romania

[19] Univ Med & Pharm Carol Davila, Bucharest, Romania

[20] Canc Registry Norway, Oslo, Norway

[21] Univ Aberdeen, Sch Med, Aberdeen AB9 2ZD, Scotland

[22] Univ Padua, Padua, Italy

[23] Inst Hyg & Epidemiol, CR-10042 Prague, Czech Republic

[24] Inst Catala Oncol, Barcelona, Spain

[25] Univ Newcastle, Sch Dent, Newcastle Upon Tyne, Tyne & Wear, England

[26] Palacky Univ, CR-77147 Olomouc, Czech Republic

[27] Univ Glasgow, Sch Dent, Glasgow, Lanark, Scotland

[28] Univ Leeds, Ctr Biostat & Epidemiol, Leeds, W Yorkshire, England

[29] NHS Natl Serv Scotland, Informat Serv Div, Edinburgh, Midlothian, Scotland

[30] Croatian Natl Canc Registry, Zagreb, Croatia

[31] Specialized State Hlth Inst, Banska Bystrica, Slovakia

[32] Maria Sklodowska Curie Mem Canc Ctr, Warsaw, Poland

[33] Inst Oncol, Warsaw, Poland

[34] Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA

来源：

NATURE GENETICS | 2008年 / 40卷 / 06期

关键词：

D O I：

10.1038/ng.151

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Alcohol is an important risk factor for upper aerodigestive cancers and is principally metabolized by alcohol dehydrogenase (ADH) enzymes. We have investigated six ADH genetic variants in over 3,800 aerodigestive cancer cases and 5,200 controls from three individual studies. Gene variants rs1229984 (ADH1B) and rs1573496 (ADH7) were significantly protective against aerodigestive cancer in each individual study and overall (P = 10(-10) and 10(-9), respectively). These effects became more apparent with increasing alcohol consumption (P for trend = 0.0002 and 0.065, respectively). Both gene effects were independent of each other, implying that multiple ADH genes may be involved in upper aerodigestive cancer etiology.

引用

页码：707 / 709

页数：3

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