In vivo studies with antisense oligonucleotides

被引:196
作者
Akhtar, S [1 ]
Agrawal, S [1 ]
机构
[1] HYBRIDON INC, WORCESTER, MA 01605 USA
关键词
D O I
10.1016/S0165-6147(96)01002-4
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
[No abstract available]
引用
收藏
页码:12 / 18
页数:7
相关论文
共 61 条
[1]   PHARMACOKINETICS, BIODISTRIBUTION, AND STABILITY OF OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATES IN MICE [J].
AGRAWAL, S ;
TEMSAMANI, J ;
TANG, JY .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (17) :7595-7599
[2]   OLIGODEOXYNUCLEOSIDE PHOSPHORAMIDATES AND PHOSPHOROTHIOATES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS [J].
AGRAWAL, S ;
GOODCHILD, J ;
CIVEIRA, MP ;
THORNTON, AH ;
SARIN, PS ;
ZAMECNIK, PC .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (19) :7079-7083
[3]   Antisense oligonucleotides: Towards clinical trials [J].
Agrawal, S .
TRENDS IN BIOTECHNOLOGY, 1996, 14 (10) :376-387
[4]   ABSORPTION, TISSUE DISTRIBUTION AND IN-VIVO STABILITY IN RATS OF A HYBRID ANTISENSE OLIGONUCLEOTIDE FOLLOWING ORAL-ADMINISTRATION [J].
AGRAWAL, S ;
ZHANG, XS ;
LU, ZH ;
ZHAO, H ;
TAMBURIN, JM ;
YAN, YM ;
CAI, HY ;
DIASIO, RB ;
HABUS, I ;
JIANG, ZW ;
IYER, RP ;
YU, D ;
ZHANG, RW .
BIOCHEMICAL PHARMACOLOGY, 1995, 50 (04) :571-576
[5]   PHARMACOKINETICS OF ANTISENSE OLIGONUCLEOTIDES [J].
AGRAWAL, S ;
TEMSAMANI, J ;
GALBRAITH, W ;
TANG, JY .
CLINICAL PHARMACOKINETICS, 1995, 28 (01) :7-16
[6]   Novel enzymatic and immunological responses to oligonucleotides [J].
Agrawal, S ;
Rustagi, PK ;
Shaw, DR .
TOXICOLOGY LETTERS, 1995, 82-3 :431-434
[7]  
Agrawal S., 1996, ANTISENSE THERAPEUTI
[8]   STABILITY OF ANTISENSE DNA OLIGODEOXYNUCLEOTIDE ANALOGS IN CELLULAR-EXTRACTS AND SERA [J].
AKHTAR, S ;
KOLE, R ;
JULIANO, RL .
LIFE SCIENCES, 1991, 49 (24) :1793-1801
[9]  
ATHTAR S, 1995, DELIVERY STRATEGIES
[10]   IMMUNE STIMULATION BY AN ANTISENSE OLIGOMER COMPLEMENTARY TO THE REV GENE OF HIV-1 [J].
BRANDA, RF ;
MOORE, AL ;
MATHEWS, L ;
MCCORMACK, JJ ;
ZON, G .
BIOCHEMICAL PHARMACOLOGY, 1993, 45 (10) :2037-2043