Synthesis of novel pyrazolopyrrolopyrazines, potential analogs of sildenafil

被引:43
作者
Kopp, M [1 ]
Lancelot, JC [1 ]
Dallemagne, P [1 ]
Rault, S [1 ]
机构
[1] Ctr Etud & Rech Medicament Normandie, F-14032 Caen, France
关键词
D O I
10.1002/jhet.5570380506
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Synthesis of novel pyrazolopyrrolopyrazines is herein described with the aim to reach new specific PDE5 inhibitors of potential clinical interest in male erectile dysfunction.
引用
收藏
页码:1045 / 1050
页数:6
相关论文
共 16 条
[1]  
BEAVO JA, 1994, MOL PHARMACOL, V46, P399
[2]  
BELL A, 1992, Patent No. 525034
[3]  
Bell A. S., 1992, Pyrazolopyrimidinone antianginal agents, Eur. Pat. Appl, Patent No. [463756, 463756 A1]
[4]   PREPARATION OF CIS AND TRANS 2,5-DIMETHOXY-2-(ACETAMIDOMETHYL)-2,5-DIHYDROFURAN, OF CISS AND TRANS 2,5-DIMETHOXY-2-(ACETAMIDOMETHYL)-TETRAHYDROFURAN AND OF 1-PHENYL-2-(ACETAMIDOMETHYL)-PYRROLE [J].
CLAUSONKAAS, N ;
TYLE, Z .
ACTA CHEMICA SCANDINAVICA, 1952, 6 (05) :667-670
[5]  
CORELLI F, 1988, FARMACO, V43, P251
[6]  
Ellis P, 1994, Patent No. [WO94/28902, 9428902]
[7]   THE PREPARATION OF PYRROLES FROM FURANS [J].
ELMING, N ;
CLAUSONKAAS, N .
ACTA CHEMICA SCANDINAVICA, 1952, 6 (06) :867-874
[8]   A NITRIC-OXIDE LIKE FACTOR MEDIATES NONADRENERGIC-NONCHOLINERGIC NEUROGENIC RELAXATION OF PENILE CORPUS CAVERNOSUM SMOOTH-MUSCLE [J].
KIM, N ;
AZADZOI, KM ;
GOLDSTEIN, I ;
DETEJADA, IS .
JOURNAL OF CLINICAL INVESTIGATION, 1991, 88 (01) :112-118
[9]  
LAPWORTH A, 2002, J CHEM SOC, V81, P1490
[10]  
PICTET A, 1911, CHEM BER, V44, P2034