The anticancer agent 3-bromopyruvate: a simple but powerful molecule taken from the lab to the bedside

被引:65
作者
Azevedo-Silva, J. [1 ]
Queiros, O. [1 ,2 ]
Baltazar, F. [3 ,4 ]
Uaszewski, S. [5 ]
Goffeau, A. [6 ]
Ko, Y. H. [7 ]
Pedersen, P. L. [8 ,9 ]
Preto, A. [1 ]
Casal, M. [1 ]
机构
[1] Univ Minho, Dept Biol, Ctr Mol & Environm Biol CBMA, Campus Gualtar, P-4710057 Braga, Portugal
[2] Inst Invest & Formacao Avancada Ciencias & Tecnol, CESPU, Rua Cent Gandra 1317, P-4585116 Gandra, Prd, Portugal
[3] Univ Minho, Life & Hlth Sci Res Inst ICVS, Sch Hlth Sci, Campus Gualtar, P-4710057 Braga, Portugal
[4] ICVS 3Bs PT Govt Associate Lab, Braga, Portugal
[5] Univ Wroclaw, Inst Genet & Microbiol, Przybyszewskiego 63-77, PL-51148 Wroclaw, Poland
[6] Univ Catholique Louvain la Neuve, Inst Sci Vie, 1 Pl Univ, B-1348 Louvain La Neuve, Belgium
[7] Univ Maryland BioPk, KoDiscovery LLC, Suites 502 E & F,801 West Baltimore St, Baltimore, MD 21201 USA
[8] Johns Hopkins Univ, Sch Med, Dept Biol Chem, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21205 USA
[9] Johns Hopkins Univ, Sch Med, Dept Oncol, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21205 USA
关键词
3-bromopyruvate; Monocarboxylate transporter; Cancer metabolism; Tumor microenvironment; Cancer therapy; Clinical studies; HEXOKINASE-II INHIBITOR; MITOCHONDRIAL PYRUVATE CARRIER; ENERGY BLOCKER 3-BROMOPYRUVATE; BREAST-CANCER CELLS; HEPATOCELLULAR-CARCINOMA; PANCREATIC-CANCER; ANTITUMOR AGENT; LIVER-CANCER; LEUKEMIA-CELLS; TUMOR-CELLS;
D O I
10.1007/s10863-016-9670-z
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
At the beginning of the twenty-first century, 3-bromopyruvate (3BP), a simple alkylating chemical compound was presented to the scientific community as a potent anticancer agent, able to cause rapid toxicity to cancer cells without bystander effects on normal tissues. The altered metabolism of cancers, an essential hallmark for their progression, also became their Achilles heel by facilitating 3BP's selective entry and specific targeting. Treatment with 3BP has been administered in several cancer type models both in vitro and in vivo, either alone or in combination with other anticancer therapeutic approaches. These studies clearly demonstrate 3BP's broad action against multiple cancer types. Clinical trials using 3BP are needed to further support its anticancer efficacy against multiple cancer types thus making it available to more than 30 million patients living with cancer worldwide. This review discusses current knowledge about 3BP related to cancer and discusses also the possibility of its use in future clinical applications as it relates to safety and treatment issues.
引用
收藏
页码:349 / 362
页数:14
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