Analysis of optineurin in frontotemporal lobar degeneration

被引：8
作者：
Rollinson, Sara [1 ]
Bennion, Janis [1 ]
Toulson, Greg [1 ]
Halliwell, Nicola [1 ]
Usher, Suzanne [1 ]
Snowden, Julie [2 ]
Richardson, Anna [2 ]
Neary, David [2 ]
Mann, David [2 ]
Pickering-Brown, Stuart M. [1 ]
机构：
[1] Univ Manchester, Neurodegenerat & Mental Hlth Res Grp, Fac Human & Med Sci, Manchester M13 9PT, Lancs, England
[2] Hope Hosp, Greater Manchester Neurosci Ctr, Salford M6 8HD, Lancs, England
来源：
NEUROBIOLOGY OF AGING | 2012年 / 33卷 / 02期
基金：
英国惠康基金; 英国医学研究理事会;
关键词：
Frontotemporal lobar degeneration; FTLD; optineurin; AMYOTROPHIC-LATERAL-SCLEROSIS;
D O I：
10.1016/j.neurobiolaging.2010.10.002
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Frontotemporal lobar degeneration (FTLD) can occur jointly with amyotrophic lateral sclerosis (ALS), and these 2 conditions share a genetic risk factor on chromosome 9. It has been reported that mutations in optineurin (OPTN) can cause ALS. Therefore, we sequenced OPTN in 371 FTLD cases but no mutations were detected, suggesting changes in OPTN do not cause FTLD. (C) 2012 Elsevier Inc. All rights reserved.
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收藏
页码：425.e1 / 425.e2
页数：2
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