Competitive inhibition of mushroom tyrosinase by 4-substituted benzaldehydes

被引：141

作者：

Jiménez, M ^{[1
]}

Chazarra, S ^{[1
]}

Escribano, J ^{[1
]}

Cabanes, J ^{[1
]}

García-Carmona, F ^{[1
]}

机构：

[1] Univ Murcia, Dept Bioquim & Biol Mol A, Unidad Docente Biol, E-30080 Murcia, Spain

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2001年 / 49卷 / 08期

关键词：

tyrosinase; monophenolase; diphenolase; cuminaldehyde; competitive inhibitors;

D O I：

10.1021/jf010194h

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

A kinetic study of the inhibition of mushroom tyrosinase by 4-substituted benzaldehydes showed that these compounds behave as classical competitive inhibitors, inhibiting the oxidation Of L-3,4-dihydroxyphenylalanine (L-DOPA) by mushroom tyrosinase (o-diphenolase activity). The kinetic parameter (K-I) characterizing this inhibition was evaluated for all of the seven compounds assayed. Cuminaldehyde showed the most potent inhibitory activity (K-I = 9 muM). It also inhibited the oxidation of L-tyrosine by mushroom tyrosinase (o-monophenolase activity) in a competitive manner. The corresponding kinetic parameter for this inhibition was evaluated (K-I = 0.12 mM).

引用

页码：4060 / 4063

页数：4

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