Well-defined biohybrids using reversible-deactivation radical polymerization procedures

被引：57

作者：

Averick, Saadyah ^{[1
]}

Mehl, Ryan A. ^{[2
]}

Das, Subha R. ^{[3
,4
]}

Matyjaszewski, Krzysztof ^{[4
]}

机构：

[1] Allegheny Hlth Network Res Inst, Lab Bimol Med, Pittsburgh, PA 15212 USA

[2] Oregon State Univ, Dept Biochem & Biophys, Corvallis, OR 97331 USA

[3] Carnegie Mellon Univ, Ctr Nucle Acids Sci & Technol, Pittsburgh, PA 15213 USA

[4] Carnegie Mellon Univ, Dept Chem, Pittsburgh, PA 15213 USA

来源：

JOURNAL OF CONTROLLED RELEASE | 2015年 / 205卷

基金：

美国国家科学基金会;

关键词：

RDRP; ATRP; RAFT; Bioconjugates; Biohybrids; Polymer; IN-SITU GROWTH; CLICK CHEMISTRY; AMINO-ACIDS; RESPONSIVE POLYMER; STEM-CELLS; C-TERMINUS; PROTEIN; DNA; CONJUGATION; PEGYLATION;

D O I：

10.1016/j.jconrel.2014.11.030

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The use of reversible deactivation radical polymerization (RDRP) methods has significantly expanded the field of bioconjugate synthesis. RDRP procedures have allowed the preparation of a broad range of functional materials that could not be realized using prior art poly(ethylene glycol) functionalization. The review of procedures for synthesis of biomaterials is presented with a special focus on the use of RDRP to prepare biohybrids with proteins, DNA and RNA. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：45 / 57

页数：13

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