Well-defined biohybrids using reversible-deactivation radical polymerization procedures

被引：56
作者：
Averick, Saadyah [1 ]
Mehl, Ryan A. [2 ]
Das, Subha R. [3 ,4 ]
Matyjaszewski, Krzysztof [4 ]
机构：
[1] Allegheny Hlth Network Res Inst, Lab Bimol Med, Pittsburgh, PA 15212 USA
[2] Oregon State Univ, Dept Biochem & Biophys, Corvallis, OR 97331 USA
[3] Carnegie Mellon Univ, Ctr Nucle Acids Sci & Technol, Pittsburgh, PA 15213 USA
[4] Carnegie Mellon Univ, Dept Chem, Pittsburgh, PA 15213 USA
来源：
JOURNAL OF CONTROLLED RELEASE | 2015年 / 205卷
基金：
美国国家科学基金会;
关键词：
RDRP; ATRP; RAFT; Bioconjugates; Biohybrids; Polymer; IN-SITU GROWTH; CLICK CHEMISTRY; AMINO-ACIDS; RESPONSIVE POLYMER; STEM-CELLS; C-TERMINUS; PROTEIN; DNA; CONJUGATION; PEGYLATION;
D O I：
10.1016/j.jconrel.2014.11.030
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The use of reversible deactivation radical polymerization (RDRP) methods has significantly expanded the field of bioconjugate synthesis. RDRP procedures have allowed the preparation of a broad range of functional materials that could not be realized using prior art poly(ethylene glycol) functionalization. The review of procedures for synthesis of biomaterials is presented with a special focus on the use of RDRP to prepare biohybrids with proteins, DNA and RNA. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码：45 / 57
页数：13
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