The Discovery of 5-Formylcytosine in Embryonic Stem Cell DNA

被引：380
|
作者：
Pfaffeneder, Toni [2 ]
Hackner, Benjamin [2 ]
Truss, Matthias [1 ]
Muenzel, Martin [2 ]
Mueller, Markus [2 ]
Deiml, Christian A. [2 ]
Hagemeier, Christian [1 ]
Carell, Thomas [2 ]
机构：
[1] Charite Univ Klinikum, Otto Heubner Ctr Kinder & Jugendmed, Klin Allgemeine Padiat, Lab Padiat Mol Biol, D-10098 Berlin, Germany
[2] Univ Munich, Fak Chem & Pharm, CIPSM, D-81377 Munich, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 31期
关键词：
active demethylation; epigenetics; 5-formylcytosine; 5-hydroxymethylcytosine; mass spectrometry; 5-HYDROXYMETHYLCYTOSINE; METHYLATION; 5-METHYLCYTOSINE; GENOME; TET1; DEMETHYLATION; HYDROXYMETHYLCYTOSINE; QUANTIFICATION; CONVERSION; CATALYSIS;
D O I：
10.1002/anie.201103899
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Touching base: Sophisticated mass spectrometry has shown that 5-formylcytosine is a constituent of mammalian embryonic stem cell DNA. This base is likely produced from methylcytosine via hydroxymethylcytosine (see scheme), and it may serve as an intermediate in the long searched for pathway of active DNA demethylation. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：7008 / 7012
页数：5
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