Thiol-disulfide balance: From the concept of oxidative stress to that of redox regulation

被引：207
作者：
Ghezzi, P
Bonetto, V
Fratelli, M
机构：
[1] Mario Negri Inst Pharmacol Res, I-20157 Milan, Italy
[2] Dulbecco Telethon Inst, Milan, Italy
来源：
ANTIOXIDANTS & REDOX SIGNALING | 2005年 / 7卷 / 7-8期
关键词：
D O I：
10.1089/ars.2005.7.964
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Originally, small thiols, including glutathione, were viewed as protective antioxidants, acting as free radical scavengers in the context of oxidative damage. Recently, there is a growing literature showing that protein glutathionylation (formation of protein-glutathione mixed disulfides) and other forms of cysteine oxidation may be a means of redox regulation under physiological conditions. This review discusses the importance of protein oxidation in redox regulation in view of the recent data originating from the application of redox proteomics to identify redox-sensitive targets.
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收藏
页码：964 / 972
页数：9
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