Co-crystals and salts of vanillic acid and vanillin with amines

被引：13
|
作者：
Noa, Francoise M. Amombo [1 ]
Mehlana, Gift [1 ,2 ]
机构：
[1] Univ Cape Town, Dept Chem, Ctr Supramol Chem Res, ZA-7701 Rondebosch, South Africa
[2] Midlands State Univ, Dept Chem Technol, Private Bag 9055 Senga Rd, Gweru, Zimbabwe
来源：
CRYSTENGCOMM | 2018年 / 20卷 / 07期
基金：
新加坡国家研究基金会;
关键词：
PHARMACEUTICAL COCRYSTALS; SOLUBILITY; SYNTHONS; TERNARY; DESIGN; DRUG;
D O I：
10.1039/c7ce02022h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Vanillin (VAN) and its oxidized form vanillic acid (VA) have successfully formed a series of co-crystals and salts. VAN formed a co-crystal with isonicotinamide (INM) and a co-crystal hydrate with theobromine (THB). Binary co-crystals of VA with isonicotinamide (INM), hexamethylenetetramine (HEXA), phenazine (PHZ) and pyrazine-N-oxide (PZO) were obtained. Interestingly, a ternary co-crystal resulted from a 1 : 1 : 1 ratio of VA, caffeine (CAF) and nicotinamide (NAM). Salt hydrates were also formed between piperazine (PPZ) and 1,4-diazabicyclo.2.2.2] octane (DABCO) with VA. All co-crystals and salts were characterized by X-ray diffraction techniques, thermal analysis and infrared spectroscopy.
引用
收藏
页码：896 / 905
页数：10
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