Ofatumumab in the treatment of non-Hodgkin's lymphomas

被引：10

作者：

Karlin, Lionel ^{[1
]}

Coiffier, Bertrand ^{[1
]}

机构：

[1] Hosp Civils Lyon, Ctr Hosp Lyon Sud, Dept Hematol, F-69495 Pierre Benite, France

来源：

EXPERT OPINION ON BIOLOGICAL THERAPY | 2015年 / 15卷 / 07期

关键词：

diffuse large B-cell lymphoma; follicular lymphoma; ofatumumab; B-CELL LYMPHOMA; CHRONIC LYMPHOCYTIC-LEUKEMIA; REFRACTORY FOLLICULAR LYMPHOMA; ANTI-CD20; MONOCLONAL-ANTIBODY; PHASE-II TRIAL; PLUS RITUXIMAB; TARGETING BTK; CHEMOTHERAPY; MULTICENTER; COMBINATION;

D O I：

10.1517/14712598.2015.1055241

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Introduction: Ofatumumab is a second-generation humanized monoclonal antibody targeting CD20 registered for the treatment of patients with relapsing/refractory chronic lymphocytic leukemia. This review will describe the activity of ofatumumab in patients with CD20 B-cell lymphomas. Areas covered: A review of all manuscript published on ofatumumab activity in B-cell lymphomas is presented with conclusions on the future use of this antibody in these patients. Expert opinion: Ofatumumab activity is low in indolent or aggressive B-cell lymphomas. The future of this drug is challenged by new monoclonal antibodies and new targeted drugs.

引用

页码：1085 / 1091

页数：7

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