Abietane diterpenoids from Sideritis montana L. and their antiproliferative activity

被引：14
|
作者：
Toth, Barbara [1 ]
Kusz, Norbert [1 ]
Forgo, Peter [1 ]
Bozsity, Noerni [2 ]
Zupko, Istvan [2 ,3 ]
Pinke, Gyula [4 ]
Hohmann, Judit [1 ,3 ]
Vasas, Andrea [1 ]
机构：
[1] Univ Szeged, Dept Pharmacognosy, H-6720 Szeged, Hungary
[2] Univ Szeged, Dept Pharmacodynam & Biopharm, H-6720 Szeged, Hungary
[3] Univ West Hungry, Dept Bot, H-9200 Mosonmagyarovar, Hungary
[4] Univ Szeged, Interdisciplinary Ctr Nat Prod, H-6720 Szeged, Hungary
来源：
FITOTERAPIA | 2017年 / 122卷
基金：
匈牙利科学研究基金会;
关键词：
Sideritis montana; Lamiaceae; Diterpenoids; Flavonoid; Antiproliferative activity; GLECHOMA-LONGITUBA; LARIX-KAEMPFERI; CONES;
D O I：
10.1016/j.fitote.2017.08.016
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The present study aimed at the phytochemical and pharmacological investigation of Sideritis montana L. (Lamiaceae). Two new abietane diterpenes [sideritins A (1) and B (2)] were isolated from the methanol extract of the plant. Six known compounds [pomiferin E (3), 9 alpha,13 alpha-epi-dioxyabiet-8(14)-en-18-ol (4), paulownin (5), 6-methoxysakuranetin (6), 3-oxo-alpha-ionol (7) and 4-ally1-2,6-dimethoxyphenol glucoside (8)] were also obtained from the plant. The structures were determined by means of HREIMS and NMR experiments. The anti proliferative effect of the isolated compounds was investigated on human cancer cell lines (HeLa, SiHa and C33A) at 10 and 30 mu M concentrations, using the MIT assay. The results demonstrated that pomiferin E (3) and 6-methoxysalturanetin (6) displayed considerable activity [inhibition (%) +/- SEM: 46.93 +/- 2.35 on HeLa (pomiferin E), and 51.52 +/- 2.45 on C33A (6-methoxysakuranetin)] at 30 mu M concentration.
引用
收藏
页码：90 / 94
页数：5
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