Bioactive SiO2-CaO-P2O5 hollow nanospheres for drug delivery

被引：15

作者：

Li, Bin ^{[1
]}

Luo, Wenqin ^{[2
]}

Wang, Yongya ^{[2
]}

Wu, Haiyan ^{[1
]}

Zhang, Chengcheng ^{[2
]}

机构：

[1] Huzhou Univ, Sch Life Sci, Huzhou 313000, Zhejiang, Peoples R China

[2] Huzhou Univ, Sch Engn, Huzhou 313000, Zhejiang, Peoples R China

来源：

JOURNAL OF NON-CRYSTALLINE SOLIDS | 2016年 / 447卷

基金：

中国国家自然科学基金;

关键词：

Bioactive glass; Drug delivery; Hollow nanospheres; GLASS NANOPARTICLES; SPHERES; PARTICLES;

D O I：

10.1016/j.jnoncrysol.2016.05.041

中图分类号：

TQ174 [陶瓷工业]; TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Hollow nanospherical bioactive glasses have attracted much interest in the recent years because of their important applications in drug delivery and hard tissue repair. Herein, we developed a facile method to fabricate bioactive SiO2-CaO-P2O5 (SCP) hollow nanospheres using polystyrene (PS) nanospheres as the hard template. The removal of PS templates by heating produced almost monodispersed hollow SCP nanospheres with an inner cavity of 210 nm, making them suitable for drug delivery. The impact of the glass composition on the formation of hollow SCP nanospheres was investigated in detail. High drug-loading capacity and sustained multistep release of theophylline in the SCP nanospheres were achieved. Furthermore, the SCP nanospheres exhibited apatite forming ability when immersed in a simulated body fluid. Cytotoxicity of SCP nanospheres on live cells has been evaluated. The SCP hollow nanospheres with sustained drug release property and bioactivity are promising new-generation biomaterials. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：98 / 103

页数：6

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