Solid Organ Transplantation From Hepatitis B Virus-Positive Donors: Consensus Guidelines for Recipient Management

被引：170

作者：

Huprikar, S. ^{[1
]}

Danziger-Isakov, L. ^{[2
]}

Ahn, J. ^{[3
]}

Naugler, S. ^{[3
]}

Blumberg, E. ^{[4
]}

Avery, R. K. ^{[5
]}

Koval, C. ^{[6
]}

Lease, E. D. ^{[7
]}

Pillai, A. ^{[8
]}

Doucette, K. E. ^{[9
]}

Levitsky, J. ^{[10
]}

Morris, M. I. ^{[11
]}

Lu, K. ^{[12
]}

McDermott, J. K. ^{[13
]}

Mone, T. ^{[14
]}

Orlowski, J. P. ^{[15
]}

Dadhania, D. M. ^{[16
]}

Abbott, K. ^{[17
]}

Horslen, S. ^{[18
]}

Laskin, B. L. ^{[19
]}

Mougdil, A. ^{[20
]}

Venkat, V. L. ^{[21
]}

Korenblat, K. ^{[22
]}

Kumar, V. ^{[23
]}

Grossi, P. ^{[24
]}

Bloom, R. D. ^{[4
]}

Brown, K. ^{[25
]}

Kotton, C. N. ^{[26
]}

Kumar, D. ^{[27
]}

机构：

[1] Icahn Sch Med Mt Sinai, New York, NY 10029 USA

[2] Cincinnati Childrens Hosp, Med Ctr, Cincinnati, OH USA

[3] Oregon Hlth & Sci Univ, Portland, OR USA

[4] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA

[5] Johns Hopkins, Baltimore, MD USA

[6] Cleveland Clin, Cleveland, OH 44106 USA

[7] Univ Washington, Seattle, WA 98195 USA

[8] Emory Univ Hosp, Atlanta, GA 30322 USA

[9] Univ Alberta, Edmonton, AB, Canada

[10] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA

[11] Univ Miami, Miller Sch Med, Miami, FL 33136 USA

[12] I Shou Univ, Dept Surg, Div Urol, Kaohsiung, Taiwan

[13] Spectrum Hlth, Grand Rapids, MI USA

[14] OneLegacy, Los Angeles, CA USA

[15] LifeShare Oklahoma, Oklahoma City, OK USA

[16] Cornell Univ, New York, NY 10021 USA

[17] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA

[18] Seattle Childrens Hosp, Seattle, WA USA

[19] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA

[20] Childrens Natl Med Ctr, Washington, DC 20010 USA

[21] UPMC, Pediat Childrens Hosp Pittsburgh, Pittsburgh, PA USA

[22] Washington Univ, St Louis, MO USA

[23] Univ Alabama Birmingham, Birmingham, AL USA

[24] Univ Insubria, Varese, Italy

[25] Henry Ford Hosp, Detroit, MI 48202 USA

[26] Massachusetts Gen Hosp, Boston, MA 02114 USA

[27] Univ Toronto, Toronto, ON, Canada

来源：

AMERICAN JOURNAL OF TRANSPLANTATION | 2015年 / 15卷 / 05期

关键词：

HBSAG-NEGATIVE RECIPIENTS; SURFACE-ANTIGEN; CORE ANTIBODY; KIDNEY-TRANSPLANTATION; LIVER-TRANSPLANTATION; RENAL-TRANSPLANTATION; ENTECAVIR THERAPY; UNITED NETWORK; FOLLOW-UP; INFECTION;

D O I：

10.1111/ajt.13187

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Use of organs from donors testing positive for hepatitis B virus (HBV) may safely expand the donor pool. The American Society of Transplantation convened a multidisciplinary expert panel that reviewed the existing literature and developed consensus recommendations for recipient management following the use of organs from HBV positive donors. Transmission risk is highest with liver donors and significantly lower with non-liver (kidney and thoracic) donors. Antiviral prophylaxis significantly reduces the rate of transmission to liver recipients from isolated HBV core antibody positive (anti-HBc+) donors. Organs from anti-HBc+ donors should be considered for all adult transplant candidates after an individualized assessment of the risks and benefits and appropriate patient consent. Indefinite antiviral prophylaxis is recommended in liver recipients with no immunity or vaccine immunity but not in liver recipients with natural immunity. Antiviral prophylaxis may be considered for up to 1 year in susceptible non-liver recipients but is not recommended in immune non-liver recipients. Although no longer the treatment of choice in patients with chronic HBV, lamivudine remains the most cost-effective choice for prophylaxis in this setting. Hepatitis B immunoglobulin is not recommended.

引用

页码：1162 / 1172

页数：11

共 85 条

[1]

A Comprehensive Immunization Strategy to Eliminate Transmission of Hepatitis B Virus Infection in the United States Recommendations of the Advisory Committee on Immunization Practices, 2005, MMWR-MORBID MORTAL W, P1

[2] Sirolimus: More cause for alarm? [J].