Lipid and poly (ethylene glycol)-conjugated bi-functionalized chlorine e6 micelles for NIR-light induced photodynamic therapy

被引：17

作者：

Muddineti, Omkara Swami ^{[1
]}

Rompicharla, Sri Vishnu Kiran ^{[1
]}

Kumari, Preeti ^{[1
]}

Bhatt, Himanshu ^{[1
]}

Ghosh, Balaram ^{[1
]}

Biswas, Swati ^{[1
]}

机构：

[1] Birla Inst Technol & Sci Pilani, Dept Pharm, Hyderabad Campus, Hyderabad 500078, Telangana, India

来源：

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY | 2020年 / 29卷

关键词：

Chlorin e6; Photodynamic therapy; Polyethylene glycol; Micelles; Cancer; PEG-PE MICELLES; CANCER; PHOTOSENSITIZERS; NANOPARTICLES; EFFICACY;

D O I：

10.1016/j.pdpdt.2019.101633

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: To develop a photosensitizer, chlorin e6 (Ce6)-based amphiphilic polymer, DP-Ce6, where DOPE and PEG are conjugated to Ce6, which would self-assemble to form polymeric micelles (DP-Ce6-M) in aqueous environment. Methods: DP-Ce6-M were characterized for particle size, zeta potential, and singlet oxygen (O-1(2)) generation. Cellular internalization, phototoxicity were investigated against monolayer and 3D spheroids of human lung adenocarcinoma cells (A549). Results and conclusions: DP-Ce6-M formed stable micelles with particles size of 58.2 +/- 1.6 nm. Solubility of Ce6 was improved. Photoactivity of DP-Ce6-M was sustained in regard to O-1(2) generation compared to free Ce6. The DP-Ce6-M showed enhanced internalization and growth inhibition in monolayer and spheroidal cells. Overall, DP-Ce6-M demonstrated the potential for further exploration as PDT agent for cancer treatment.

引用

页数：10

共 31 条

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