Inflammation and cancer: Role of nuclear factor-kappaB activation

被引：188
作者：
Maeda, Shin [1 ,2 ]
Omata, Masao [2 ]
机构：
[1] Asahi Life Fdn, Inst Adult Dis, Div Gastroenterol, Chiyoda Ku, Tokyo 1000005, Japan
[2] Univ Tokyo, Dept Gastroenterol, Bunkyo Ku, Tokyo 1138655, Japan
来源：
CANCER SCIENCE | 2008年 / 99卷 / 05期
关键词：
D O I：
10.1111/j.1349-7006.2008.00763.x
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
It has been thought that there is a strong relationship between inflammation and carcinogenesis so that the development of cancer occurs with chronic inflammation in many organs. An in-depth understanding of the mechanism by which inflammation can lead to carcinogenesis may enable the development of drugs targeted at important molecules, providing a powerful tool for preventing cancer development. In this review, we focused on a signal transduction system, the nuclear factor-kappaB (NF-kappa B) pathway, which is thought to play a role in the process leading from inflammation to carcinogenesis, and may thus serve as a candidate for targeted intervention.
引用
收藏
页码：836 / 842
页数：7
相关论文
共 64 条
[1]   Oxidative stress and lipid peroxidation-derived DNA-lesions in inflammation driven carcinogenesis [J].
Bartsch, H ;
Nair, J .
CANCER DETECTION AND PREVENTION, 2004, 28 (06) :385-391
[2]   TGF-β suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling [J].
Becker, C ;
Fantini, MC ;
Schramm, C ;
Lehr, HA ;
Wirtz, S ;
Nikolaev, A ;
Burg, J ;
Strand, S ;
Kiesslich, R ;
Huber, S ;
Ito, H ;
Nishimoto, N ;
Yoshizaki, K ;
Nishimoto, N ;
Galle, PR ;
Blessing, M ;
Rose-John, S ;
Neurath, MF .
IMMUNITY, 2004, 21 (04) :491-501
[3]   NF-κB activation mediates doxorubicin-induced cell death in N-type neuroblastoma cells [J].
Bian, X ;
McAllister-Lucas, LM ;
Shao, F ;
Schumacher, KR ;
Feng, ZW ;
Porter, AG ;
Castle, VP ;
Opipari, AW .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (52) :48921-48929
[4]  
Bodger K, 1998, BRIT MED BULL, V54, P139
[5]   The two NF-κB activation pathways and their role in innate and adaptive immunity [J].
Bonizzi, G ;
Karin, M .
TRENDS IN IMMUNOLOGY, 2004, 25 (06) :280-288
[6]   cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors [J].
Censini, S ;
Lange, C ;
Xiang, ZY ;
Crabtree, JE ;
Ghiara, P ;
Borodovsky, M ;
Rappuoli, R ;
Covacci, A .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (25) :14648-14653
[7]   BAFF-induced NEMO-independent processing of NF-κB2 in maturing B cells [J].
Claudio, E ;
Brown, K ;
Park, S ;
Wang, HS ;
Siebenlist, U .
NATURE IMMUNOLOGY, 2002, 3 (10) :958-965
[8]   CD40 regulates the processing of NF-κB2 p100 to p52 [J].
Coope, HJ ;
Atkinson, PGP ;
Huhse, B ;
Belich, M ;
Janzen, J ;
Holman, MJ ;
Klaus, GGB ;
Johnston, LH ;
Ley, SC .
EMBO JOURNAL, 2002, 21 (20) :5375-5385
[9]   Inflammation and cancer [J].
Coussens, LM ;
Werb, Z .
NATURE, 2002, 420 (6917) :860-867
[10]   The lymphotoxin-β receptor induces different patterns of gene expression via two NF-κB pathways [J].
Dejardin, E ;
Droin, NM ;
Delhase, M ;
Haas, E ;
Cao, YX ;
Makris, C ;
Li, ZW ;
Karin, M ;
Ware, CF ;
Green, DR .
IMMUNITY, 2002, 17 (04) :525-535
1234567