Inflammation and cancer: Role of nuclear factor-kappaB activation

被引：186
作者：
Maeda, Shin [1 ,2 ]
Omata, Masao [2 ]
机构：
[1] Asahi Life Fdn, Inst Adult Dis, Div Gastroenterol, Chiyoda Ku, Tokyo 1000005, Japan
[2] Univ Tokyo, Dept Gastroenterol, Bunkyo Ku, Tokyo 1138655, Japan
来源：
CANCER SCIENCE | 2008年 / 99卷 / 05期
关键词：
D O I：
10.1111/j.1349-7006.2008.00763.x
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
It has been thought that there is a strong relationship between inflammation and carcinogenesis so that the development of cancer occurs with chronic inflammation in many organs. An in-depth understanding of the mechanism by which inflammation can lead to carcinogenesis may enable the development of drugs targeted at important molecules, providing a powerful tool for preventing cancer development. In this review, we focused on a signal transduction system, the nuclear factor-kappaB (NF-kappa B) pathway, which is thought to play a role in the process leading from inflammation to carcinogenesis, and may thus serve as a candidate for targeted intervention.
引用
收藏
页码：836 / 842
页数：7
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