Hepatitis E virus: complete genome sequence and phylogenetic analysis of a Nepali isolate

被引：35
作者：
Gouvea, V
Snellings, N
Popek, MJ
Longer, CF
Innis, BL
机构：
[1] Walter Reed Army Inst Res, Dept Virus Dis, Washington, DC 20307 USA
[2] Walter Reed Army Inst Res, Dept Bacterial Dis, Washington, DC 20307 USA
来源：
VIRUS RESEARCH | 1998年 / 57卷 / 01期
关键词：
hepatitis E; HEV; complete HEV sequence; phylogeny; hypervariable region;
D O I：
10.1016/S0168-1702(98)00079-3
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The complete nucleotide sequence of the Nepali strain TK15/92 of hepatitis E (HEV) was determined. It showed the highest sequence homology with the Burmese B1 strain, but closer evolutionary relatedness to the Indian strains. Difficulties in reverse-transcribing and amplifying the hypervariable region in ORF1 suggested that strong secondary structures might be intrinsically responsible for the high mutational rate observed in this region of the HEV genome. (C) 1998 Elsevier Science B.V. All rights reserved.
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页码：21 / 26
页数：6
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