Infection and inflammation: New perspectives on Alzheimer's disease

被引：17

作者：

Whitson, Heather E. ^{[1
,19
]}

Colton, Carol ^{[2
]}

El Khoury, Joseph ^{[3
]}

Gate, David ^{[4
]}

Goate, Alison ^{[5
]}

Heneka, Michael T. ^{[6
]}

Kaddurah-Daouk, Rima ^{[7
]}

Klein, Robyn S. ^{[8
,9
,10
]}

Shinohara, Mari L. ^{[11
]}

Sisodia, Sangram ^{[12
]}

Spudich, Serena S. ^{[13
]}

Stevens, Beth ^{[14
]}

Tanzi, Rudolph ^{[15
]}

Ting, Jenny P. ^{[16
,17
]}

Garden, Gwenn ^{[18
]}

机构：

[1] Duke Univ, Duke Ctr Study Aging & Human Dev, Sch Med, Busse Bldg Rm 3502, Durham, NC 27710 USA

[2] Duke Univ, Dept Neurol, Sch Med, 3116 N Duke St, Durham, NM 27704 USA

[3] Massachusetts Gen Hosp, Ctr Immunol & Inflammatory Dis, Div Infect Dis, 55 Fruit St, Boston, MA 02114 USA

[4] Northwestern Univ, Feinberg Sch Med, Ken & Ruth Davee Dept Neurol, 303 Chicago Ave,Ward 12 140, Chicago, IL 60611 USA

[5] Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, One Gustave L Levy Pl,Box 1498, New York, NY 10029 USA

[6] Univ Bonn Med Ctr, Dept Neurodegenerat Dis & Geriatr Psychiat Neurol, Sigmund Freud Str 25, D-53127 Bonn, Germany

[7] Duke Univ, Duke Inst Brain Sci, Dept Psychiat & Behav Sci, Dept Med,Sch Med, DUMC Box 3903,Blue Zone,South, Durham, NC 27710 USA

[8] Washington Univ, Ctr Neuroimmunol & Neuroinfect Dis, Dept Med, Sch Med, 660 S Euclid Ave,Box 8015, St Louis, MO 63110 USA

[9] Washington Univ, Dept Pathol & Immunol, Sch Med, 660 S Euclid Ave,Box 8015, St Louis, MO 63110 USA

[10] Washington Univ, Dept Neurosci, Sch Med, 660 S Euclid Ave,Box 8015, St Louis, MO 63110 USA

[11] Duke Univ, Dept Immunol, Sch Med, 207 Res Dr,Box 3010, Durham, NC 27710 USA

[12] Univ Chicago, Dept Neurobiol, Abbott Mem Hall,947 East 58th St,MC 0928, Chicago, IL 60637 USA

[13] Yale Sch Med, Dept Neurol, POB 208018, New Haven, CT 06520 USA

[14] Childrens Hosp Boston, FM Kirby Neurobiol Ctr, 300 Longwood Ave,Ctr Life Sci 12 Floor, Boston, MA 02115 USA

[15] Massachusetts Gen Hosp, McCance Ctr Brain Hlth, 114 16th St, Charlestown, MA 02129 USA

[16] UNC Sch Med, Lineberger Comprehens Canc Ctr, Ctr Translat Immunol, Dept Genet, 125 Mason Farm Rd,6th Floor Mars Hall, Chapel Hill, NC 27599 USA

[17] UNC Sch Med, Lineberger Comprehens Canc Ctr, Ctr Translat Immunol, Dept Microbiol & Immunol, 125 Mason Farm Rd,6th Floor Mars Hall, Chapel Hill, NC 27599 USA

[18] UNC Sch Med, Dept Neurol, Phys Off Bldg,170 Manning Dr,Campus Box 7025, Chapel Hill, NC 27599 USA

[19] Durham VA Med Ctr, Geriatr Res Educ & Clin Ctr, 508 Fulton St, Durham, NC 27705 USA

来源：

BRAIN BEHAVIOR & IMMUNITY-HEALTH | 2022年 / 22卷

关键词：

Alzheimer 's; Inflammation; Infection; Microglia; Inflammasome; Microbe; Fungi; Microbiome; Metabolism; MOUSE MODEL; AMYLOID-BETA; MICROGLIA; NLRP3; EXPRESSION; TAU; NEUROINFLAMMATION; ACTIVATION; MICROBIOTA; DECTIN-1;

D O I：

10.1016/j.bbih.2022.100462

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Neuroinflammation has been recognized as a component of Alzheimer's Disease (AD) pathology since the original descriptions by Alois Alzheimer and a role for infections in AD pathogenesis has long been hypothesized. More recently, this hypothesis has gained strength as human genetics and experimental data suggest key roles for inflammatory cells in AD pathogenesis. To review this topic, Duke/University of North Carolina (Duke/UNC) Alzheimer's Disease Research Center hosted a virtual symposium: "Infection and Inflammation: New Perspectives on Alzheimer's Disease (AD)." Participants considered current evidence for and against the hypothesis that AD could be caused or exacerbated by infection or commensal microbes. Discussion focused on connecting microglial transcriptional states to functional states, mouse models that better mimic human immunity, the potential involvement of inflammasome signaling, metabolic alterations, self-reactive T cells, gut microbes and fungal infections, and lessons learned from Covid-19 patients with neurologic symptoms. The content presented in the symposium, and major topics raised in discussions are reviewed in this summary of the proceedings.

引用

页数：9

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