Synthesis of Pyrimido[4,5-e]tetrazolo[5,1-b][1,3,4]thiadiazepine as a Novel Fused Heterocyclic System

被引：0

作者：

Igei, Mansoore ^{[1
]}

Shiri, Ali ^{[1
]}

Bakavoli, Mehdi ^{[1
]}

Azizollahi, Hamid ^{[1
]}

机构：

[1] Ferdowsi Univ Mashhad, Dept Chem, Fac Sci, Mashhad 917751436, Razavi Khorasan, Iran

来源：

POLYCYCLIC AROMATIC COMPOUNDS | 2020年 / 40卷 / 02期

关键词：

2; 4-Dichloro-5-(chloromethyl)-6-methylpyrimidine; heterocyclization; pyrimidotetrazolothiadiazepine; SOLID SUPPORT SYNTHESIS; 5-HALO-1,2,3-THIADIAZOLES; DERIVATIVES;

D O I：

10.1080/10406638.2018.1458740

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Several derivatives of the novel fused seven-membered heterocyclic system of pyrimido[4,5-e]tetrazolo[5,1-b][1,3,4]thiadiazepine (5a-f) have been synthesized through the heterocyclization reaction of 2,4-dichloro-5-(chloromethyl)-6-methylpyrimidine (1) with sodium 1-amino-1H-tetrazole-5-thiolate (2) under basic conditions. Various derivatives were obtained via treatment with secondary amines.

引用

页码：535 / 539

页数：5

共 25 条

[21] Synthesis and Antibacterial Activity of Some Novel 6-(1H-Benz[d]imidazol-2-yl)-8-(5-nitro-2-furyl)-3-(4-pyridyl)-7,8-dihydro[1,2,4]triazolo[3,4-b][1,3,4]thiadiazepines [J].

Reddy, Vanga Malla ;

Reddy, Kunduru Ravinder .

CHEMICAL & PHARMACEUTICAL BULLETIN, 2010, 58 (08) :1081-1084

[22] Synthesis and biological evaluation of quinolines, thiazolo[3,2-a]pyrimidines, thiadiazolo[3,2-a]pyrimidines and triazolo[3,4-b][1,3,4]thiadiazepines as antimicrobial agents [J].

Sahi, Seema ;

Paul, Satya .

MEDICINAL CHEMISTRY RESEARCH, 2016, 25 (05) :951-969

[23] Transformation of methyl N-methyl-N-(6-substituted-5-nitro-4-pyrimidinyl)aminoacetates into 4-methylamino-5-nitrosopyrimidines and 9-methylpurin-8-ones [J].

Susvilo, I ;

Brukstus, A ;

Tumkevicius, S .

TETRAHEDRON LETTERS, 2005, 46 (11) :1841-1844

[24] Reaction of 5-halo-1,2,3-thiadiazoles with aliphatic diamines. Synthesis and intramolecular cyclization of bis(1,2,3-triazolyl-1,2,3-thiadiazolyl)sulfides [J].

Volkova, NN ;

Tarasov, EV ;

Kodess, MI ;

Van Meervelt, L ;

Dehaen, W ;

Bakulev, VA .

ORGANIC & BIOMOLECULAR CHEMISTRY, 2003, 1 (22) :4030-4038

[25] Reaction of 5-halo-1,2,3-thiadiazoles with arylenediamines as a new approach to tricyclic 1,3,6-thiadiazepines [J].

Volkova, NN ;

Tarasov, EV ;

Van Meervelt, L ;

Toppet, S ;

Dehaen, W ;

Bakulev, VA .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 2002, (13) :1574-1580

← 1 2 3 →