Prion and Cu2+

被引：0
|
作者：
Li, N [1 ]
Qin, JC [1 ]
机构：
[1] Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Peoples R China
来源：
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS | 2001年 / 28卷 / 05期
关键词：
copper(Cu2+); PrPC; PrPSc; prion;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Since Prusiner, suggested the prion hypothesis in 1982, a wealth of experiments have supported it to be true. However, the function of the cellular prion protein (PrPC) remains unclear. But recently evidence is showing that PrPC could specifically bind to Cu2+ and may transport Cu2+ to SOD1 by endocytosis from the plasma membrane via clathrin-coated pits so that taking part in copper metabolism. Moreover, other evidence also shows that Cu2+ could enhance the reversibility of denatured PrPSc and may determine the difference of some PrPSc strains.
引用
收藏
页码：615 / 618
页数：4
相关论文
共 19 条
  • [1] Spongiform encephalopathies - B lymphocytes and neuroinvasion
    Brown, P
    [J]. NATURE, 1997, 390 (6661) : 662 - 663
  • [2] Brown DR, 1998, J NEUROCHEM, V70, P1686
  • [3] Prion protein expression and superoxide dismutase activity
    Brown, DR
    Besinger, A
    [J]. BIOCHEMICAL JOURNAL, 1998, 334 : 423 - 429
  • [4] Reversibility of scrapie inactivation is enhanced by copper
    McKenzie, D
    Bartz, J
    Mirwald, J
    Olander, D
    Marsh, R
    Aiken, J
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (40) : 25545 - 25547
  • [5] Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein Doppel
    Moore, RC
    Lee, IY
    Silverman, GL
    Harrison, PM
    Strome, R
    Heinrich, C
    Karunaratne, A
    Pasternak, SH
    Chishti, MA
    Liang, Y
    Mastrangelo, P
    Wang, K
    Smit, AFA
    Katamine, S
    Carlson, GA
    Cohen, FE
    Prusiner, SB
    Melton, DW
    Tremblay, P
    Hood, LE
    Westaway, D
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 1999, 292 (04) : 797 - 817
  • [6] Membrane environment alters the conformational structure of the recombinant human prion protein
    Morillas, M
    Swietnicki, W
    Gambetti, P
    Surewicz, WK
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (52) : 36859 - 36865
  • [7] PURIFICATION AND PROPERTIES OF THE CELLULAR PRION PROTEIN FROM SYRIAN-HAMSTER BRAIN
    PAN, KM
    STAHL, N
    PRUSINER, SB
    [J]. PROTEIN SCIENCE, 1992, 1 (10) : 1343 - 1352
  • [8] Copper stimulates endocytosis of the prion protein
    Pauly, PC
    Harris, DA
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (50) : 33107 - 33110
  • [9] Genetic neurodegenerative diseases: The human illness and transgenic models
    Price, DL
    Sisodia, SS
    Borchelt, DR
    [J]. SCIENCE, 1998, 282 (5391) : 1079 - 1083
  • [10] NOVEL PROTEINACEOUS INFECTIOUS PARTICLES CAUSE SCRAPIE
    PRUSINER, SB
    [J]. SCIENCE, 1982, 216 (4542) : 136 - 144
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