Tamoxifen retinopathy: a case report

被引:12
作者
Wang, Lingling [1 ,2 ,3 ]
Miao, Heng [1 ,2 ,3 ]
Li, Xiaoxin [1 ,2 ,3 ]
机构
[1] Peking Univ, Peoples Hosp, Dept Ophthalmol, Beijing 100044, Peoples R China
[2] Minist Educ, Key Lab Vis Loss & Restorat, Beijing, Peoples R China
[3] Beijing Key Lab Diag & Therapy Retinal & Choroid, Beijing, Peoples R China
关键词
Tamoxifen; Retinopathy; Spectral-domain optical coherence tomography; Electro-oculogram; BREAST-CANCER; CELL-DEATH; TOXICITY;
D O I
10.1186/s40064-015-1258-2
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Purpose: To present a case of tamoxifen retinopathy on a 57-year-old woman. Design: An observational case. Methods: A review of history, clinical examination, and findings on Spectral-domain Optical Coherence Tomography (SD-OCT), fluorescein angiogram (FA) and electro-oculogram (EOG) was conducted. Results: A 57-year old female patient, who had been treated with oral tamoxifen after mastectomy due to breast cancer, had profound visual impairment in both eyes. Disruption of the ellipsoid zone and interdigitation zone which represent photoreceptor damage as well as macular thinning was revealed on SD-OCT in both eyes. Bilateral retinal pigmented epithelium (RPE) function compromised was indicated by reduced Arden ratio in EOG. Conclusion: Tamoxifen-induced retinopathy could be detected by SD-OCT and EOG. As it is irreversible, patients who are given tamoxifen need regular ophthalmic consultation, including SD-OCT and EOG before and during the treatment in order to early detect and avoid further retinal damage.
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页数:4
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