A Gli(1)ttering Role for Perivascular Stem Cells in Blood Vessel Remodeling

被引：23

作者：

Baker, Andrew H. ^{[1
]}

Peault, Bruno ^{[1
,2
,3
,4
]}

机构：

[1] Univ Edinburgh, Ctr Cardiovasc Sci, Edinburgh EH16 4TJ, Midlothian, Scotland

[2] Univ Edinburgh, Ctr Regenerat Med, MRC, Edinburgh EH16 4UU, Midlothian, Scotland

[3] Univ Calif Los Angeles, Orthopaed Hosp, Res Ctr, Los Angeles, CA 90024 USA

[4] Univ Calif Los Angeles, Broad Stem Cell Ctr, Los Angeles, CA 90024 USA

来源：

Cell Stem Cell | 2016年 / 19卷 / 05期

基金：

英国医学研究理事会;

关键词：

NICHE;

D O I：

10.1016/j.stem.2016.10.011

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Blood vessels significantly remodel in response to injury and pathologic conditions, although the contribution of stem cells to this process is unclear. Now in Cell Stem Cell, Kramann et al. ( 2016) show that Gli1+ perivascular cells in the outermost vessel layer are progenitors that substantially contribute to pathologic vessel remodeling.

引用

页码：563 / 565

页数：4

共 10 条

[1] Endothelial-to-mesenchymal transition drives atherosclerosis progression [J].

Chen, Pei-Yu ;

Qin, Lingfeng ;

Baeyens, Nicolas ;

Li, Guangxin ;

Afolabi, Titilayo ;

Budatha, Madhusudhan ;

Tellides, George ;

Schwartz, Martin A. ;

Simons, Michael .

JOURNAL OF CLINICAL INVESTIGATION, 2015, 125 (12) :4514-4528

[2] The Tunica Adventitia of Human Arteries and Veins As a Source of Mesenchymal Stem Cells [J].

Corselli, Mirko ;

Chen, Chien-Wen ;

Sun, Bin ;

Yap, Solomon ;

Rubin, J. Peter ;

Peault, Bruno .

STEM CELLS AND DEVELOPMENT, 2012, 21 (08) :1299-1308

[3] A perivascular origin for mesenchymal stem cells in multiple human organs [J].

Crisan, Mihaela ;

Yap, Solomon ;

Casteilla, Louis ;

Chen, Chien-Wen ;

Corselli, Mirko ;

Park, Tea Soon ;

Andriolo, Gabriella ;

Sun, Bin ;

Zheng, Bo ;

Zhang, Li ;

Norotte, Cyrille ;

Teng, Pang-Ning ;

Traas, Jeremy ;

Schugar, Rebecca ;

Deasy, Bridget M. ;

Badylak, Stephen ;

Buehring, Hans-Joerg ;

Giacobino, Jean-Paul ;

Lazzari, Lorenza ;

Huard, Johnny ;

Peault, Bruno .

CELL STEM CELL, 2008, 3 (03) :301-313

[4] Adventitial MSC-like Cells Are Progenitors of Vascular Smooth Muscle Cells and Drive Vascular Calcification in Chronic Kidney Disease [J].

Kramann, Rafael ;

Goettsch, Claudia ;

Wongboonsin, Janewit ;

Iwata, Hiroshi ;

Schneider, Rebekka K. ;

Kuppe, Christoph ;

Kaesler, Nadine ;

Chang-Panesso, Monica ;

Machado, Flavia G. ;

Gratwohl, Susannah ;

Madhurima, Kaushal ;

Hutcheson, Joshua D. ;

Jain, Sanjay ;

Aikawa, Elena ;

Humphreys, Benjamin D. .

Cell Stem Cell, 2016, 19 (05) :628-642

[5] Perivascular Gli1+ Progenitors Are Key Contributors to Injury-Induced Organ Fibrosis [J].

Kramann, Rafael ;

Schneider, Rebekka K. ;

DiRocco, Derek P. ;

Machado, Flavia ;

Fleig, Susanne ;

Bondzie, Philip A. ;

Henderson, Joel M. ;

Ebert, Benjamin L. ;

Humphreys, Benjamin D. .

CELL STEM CELL, 2015, 16 (01) :51-66

[6] The Adventitia: A Progenitor Cell Niche for the Vessel Wall [J].

Majesky, Mark W. ;

Dong, Xiu Rong ;

Hoglund, Virginia ;

Daum, Gunter ;

Mahoney, William M., Jr. .

CELLS TISSUES ORGANS, 2012, 195 (1-2) :73-81

[7] Smooth Muscle Cell Plasticity Fact or Fiction? [J].

Nguyen, Anh T. ;

Gomez, Delphine ;

Bell, Robert D. ;

Campbell, Julie H. ;

Clowes, Alexander W. ;

Gabbiani, Giulio ;

Giachelli, Cecilia M. ;

Parmacek, Michael S. ;

Raines, Elaine W. ;

Rusch, Nancy J. ;

Speer, Mei Y. ;

Sturek, Michael ;

Thyberg, Johan ;

Towler, Dwight A. ;

Weiser-Evans, Mary C. ;

Yan, Chen ;

Miano, Joseph M. ;

Owens, Gary K. .

CIRCULATION RESEARCH, 2013, 112 (01) :17-22

[8] Contribution of adventitial fibroblasts to neointima formation and vascular remodeling - From innocent bystander to active participant [J].

Sartore, S ;

Chiavegato, A ;

Faggin, E ;

Franch, R ;

Puato, M ;

Ausoni, S ;

Pauletto, P .

CIRCULATION RESEARCH, 2001, 89 (12) :1111-1121

[9] KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis [J].

Shankman, Laura S. ;

Gomez, Delphine ;

Cherepanova, Olga A. ;

Salmon, Morgan ;

Alencar, Gabriel F. ;

Haskins, Ryan M. ;

Swiatlowska, Pamela ;

Newman, Alexandra A. C. ;

Greene, Elizabeth S. ;

Straub, Adam C. ;

Isakson, Brant ;

Randolph, Gwendalyn J. ;

Owens, Gary K. .

NATURE MEDICINE, 2015, 21 (06) :628-637

[10] Secretion of Shh by a Neurovascular Bundle Niche Supports Mesenchymal Stem Cell Homeostasis in the Adult Mouse Incisor [J].

Zhao, Hu ;

Feng, Jifan ;

Seidel, Kerstin ;

Shi, Songtao ;

Klein, Ophir ;

Sharpe, Paul ;

Chai, Yang .

CELL STEM CELL, 2014, 14 (02) :160-173

← 1 →