Global Histone H3K27 Methylation Levels are Different in Localized and Metastatic Prostate Cancer

被引：37
作者：
Ellinger, Joerg [1 ]
Kahl, Philip [2 ]
von der Gathen, Johannes [1 ]
Heukamp, Lukas C. [2 ]
Guetgemann, Ines [3 ]
Walter, Bernhard [4 ]
Hofstaedter, Ferdinand [5 ]
Bastian, Patrick J. [6 ]
von Ruecker, Alexander [3 ]
Mueller, Stefan C. [1 ]
Rogenhofer, Sebastian [1 ]
机构：
[1] Univ Klinikum Bonn, Klin & Poliklin Urol & Kinderurol, D-53105 Bonn, Germany
[2] Univ Cologne, Inst Pathol, Cologne, Germany
[3] Univ Klinikum Bonn, Inst Pathol, D-53105 Bonn, Germany
[4] Univ Klinikum Erlangen, Urol Univ Klin, Erlangen, Germany
[5] Univ Klin Regensburg, Inst Pathol, Regensburg, Germany
[6] Univ Klinikum Grosshadern, Urol Klin & Poliklin, Munich, Germany
来源：
CANCER INVESTIGATION | 2012年 / 30卷 / 02期
关键词：
Histone; Methylation; H3K27; Prostate cancer; Epigenetics; MODIFICATIONS PREDICT PROGNOSIS; CPG ISLAND HYPERMETHYLATION; CELL CARCINOMA; POLYCOMB; PROGRESSION; RISK; EZH2; TRIMETHYLATION; RECURRENCE; BREAST;
D O I：
10.3109/07357907.2011.636117
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Global histone modification patterns have been shown to be a predictive factor of recurrence in various cancers. We analyzed global histone-3-lysine-27 (H3K27) methylation in prostate cancer (PCA) tissues. H3K27 mono-, di-, and tri-methylation patterns were different in nonmalignant prostate tissue, localized PCA, metastatic PCA, and castration-resistant PCA. H3K27 mono-methylation was correlated with pT-stage, capsular penetration, seminal vesicle infiltration, and Gleason score in localized PCA and may therefore indicate adverse prognosis.
引用
收藏
页码：92 / 97
页数：6
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