Structural and functional features of glycosyltransferases

被引：122
作者：
Breton, C
Mucha, J
Jeanneau, C
机构：
[1] Univ Grenoble 1, Ctr Rech Macromol Vegetales, CNRS, F-38041 Grenoble 9, France
[2] Univ Bodenkultur Wien, Zent Angew Genet, A-1190 Vienna, Austria
来源：
BIOCHIMIE | 2001年 / 83卷 / 08期
关键词：
glycosyltransferase; Golgi retention; domain structure; catalytic domain; stem;
D O I：
10.1016/S0300-9084(01)01298-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Most of the glycosylation reactions that generate the great diversity of oligosaccharide structures of eukaryotic cells occur in the Golgi apparatus. This review deals with the most recent data that provide insight into the functional organization of Golgi-resident glycosyltransferases. We also focus on the recent successes in X-ray crystal structure determination of glycosyltransferases. These new structures begin to shed light on the molecular bases accounting for donor and acceptor substrate specificities as well as catalysis. (C) 2001 Societe francaise de biochimie et biologic moleculaire/Editions scientifiques et medicales Elsevier SAS. All rights reserved.
引用
收藏
页码：713 / 718
页数：6
相关论文
共 37 条
[1]   N-glycosylation site occupancy of rat α-1,3-fucosyltransferase IV and the effect of glycosylation on enzymatic activity [J].
Baboval, T ;
Koul, O ;
Smith, FI .
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2000, 1475 (03) :383-389
[2]  
Breton C, 1996, GLYCOBIOLOGY, V6, pR7
[3]   Structure/function studies of glycosyltransferases [J].
Breton, C ;
Imberty, A .
CURRENT OPINION IN STRUCTURAL BIOLOGY, 1999, 9 (05) :563-571
[4]   Structure of the nucleotide-diphospho-sugar transferase, SpsA from Bacillus subtilis, in native and nucleotide-complexed forms [J].
Charnock, SJ ;
Davies, GJ .
BIOCHEMISTRY, 1999, 38 (20) :6380-6385
[5]   Minimal structural and glycosylation requirements for ST6Gal I activity and trafficking [J].
Chen, C ;
Colley, KJ .
GLYCOBIOLOGY, 2000, 10 (05) :531-538
[6]   Formation of insoluble oligomers correlates with ST6Gal I stable localization in the Golgi [J].
Chen, C ;
Ma, JY ;
Lazic, A ;
Backovic, M ;
Colley, KJ .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (18) :13819-13826
[7]   Golgi localization of glycosyltransferases: More questions than answers [J].
Colley, KJ .
GLYCOBIOLOGY, 1997, 7 (01) :1-13
[8]   HYDROPHOBIC CLUSTER-ANALYSIS - AN EFFICIENT NEW WAY TO COMPARE AND ANALYZE AMINO-ACID-SEQUENCES [J].
GABORIAUD, C ;
BISSERY, V ;
BENCHETRIT, T ;
MORNON, JP .
FEBS LETTERS, 1987, 224 (01) :149-155
[9]   Bovine α1,3-galactosyltransferase catalytic domain structure and its relationship with ABO histo-blood group and glycosphingolipid glycosyltransferases [J].
Gastinel, LN ;
Bignon, C ;
Misra, AK ;
Hindsgaul, O ;
Shaper, JH ;
Joziasse, DH .
EMBO JOURNAL, 2001, 20 (04) :638-649
[10]   Crystal structures of the bovine β4galactosyltransferase catalytic domain and its complex with uridine diphosphogalactose [J].
Gastinel, LN ;
Cambillau, C ;
Bourne, Y .
EMBO JOURNAL, 1999, 18 (13) :3546-3557
1234