Liraglutide accelerates colonic transit in people with type 1 diabetes and polyneuropathy: A randomised, double-blind, placebo-controlled trial

被引:19
作者
Wegeberg, Anne-Marie Langmach [1 ,2 ]
Hansen, Christian Stevns [3 ]
Farmer, Adam D. [1 ,2 ,4 ,5 ,6 ]
Karmisholt, Jesper Scott [7 ,8 ]
Drewes, Asbjorn M. [1 ,2 ,8 ]
Jakobsen, Poul Erik [7 ,8 ]
Brock, Birgitte [3 ,9 ]
Brock, Christina [1 ,2 ,10 ]
机构
[1] Aalborg Univ Hosp, Meth Sense, Dept Gastroenterol & Hepatol, Aalborg, Denmark
[2] Aalborg Univ, Dept Clin Med, Aalborg, Denmark
[3] Steno Diabet Ctr Copenhagen, Gentofte, Denmark
[4] Blizard Inst, Wingate Inst Neurogastroenterol, Ctr Neurosci & Trauma, Barts, England
[5] Queen Mary Univ London, London Sch Med & Dent, London, England
[6] Univ Hosp North Midlands, Dept Gastroenterol, Stoke On Trent, Staffs, England
[7] Aalborg Univ Hosp, Dept Endocrinol, Aalborg, Denmark
[8] Steno Diabet Ctr North Jutland, Aalborg, Denmark
[9] Aarhus Univ Hosp, Dept Clin Biochem, Aarhus, Denmark
[10] Univ Copenhagen, Dept Pharmacotherapy & Dev, Copenhagen, Denmark
关键词
Diabetes mellitus type 1; polyneuropathies; liraglutide; gastrointestinal transit; gastrointestinal motility; digestive signs and symptoms; PAN-ENTERIC PROLONGATION; GLYCEMIC CONTROL; GASTROINTESTINAL TRANSIT; PERIPHERAL NEUROPATHY; INTESTINAL MOTILITY; RECEPTOR AGONIST; HEALTHY; CAPSULE; GLP-1; INSULIN;
D O I
10.1177/2050640620925968
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background Glucagon-like peptide-1 receptor agonists, such as liraglutide, reduce hyperglycaemia and induce weight loss and are used as a treatment in diabetes. However, common adverse effects include nausea, loss of appetite and prolonged gastric emptying. It is not known whether these changes are centrally generated or if liraglutide alters the enteric motility. Objective To investigate the effects of liraglutide on gastrointestinal function and symptoms. Methods A total of 48 adults with type 1 diabetes and confirmed distal symmetric polyneuropathy were randomised to receive liraglutide 1.8 mg/day or placebo for 26 weeks. Regional transit times and motility indexes were assessed with a wireless motility capsule, whereas symptoms were evaluated using the validated gastroparesis cardinal symptom index. Results Liraglutide treatment reduced large bowel transit time (31.7%, p = 0.04) and decreased motility index (6.1%, p = 0.04) compared to placebo, whereas the groups did not differ in gastric emptying or small-bowel transit times. Liraglutide increased postprandial fullness with 29% (p = 0.01). Increased small bowel transit time was associated with decreased bloating (p = 0.008). Conclusion Liraglutide accelerates large bowel transit and decreases motility index, which may indicate better coordination of propulsive motility. This potentially improves the function of the enteric nervous system, leading to normalised colonic function and positive effects in type 1 diabetes.
引用
收藏
页码:695 / 704
页数:10
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