Epigenetic control of macrophage polarization

被引：101
作者：
Takeuch, Osamu [1 ,2 ]
Akira, Shizuo [1 ,2 ]
机构：
[1] Osaka Univ, WPI Immunol Frontier Res Ctr IFReC, Host Def Lab, Suita, Osaka 5650871, Japan
[2] Osaka Univ, Microbial Dis Res Inst, Suita, Osaka 5650871, Japan
来源：
EUROPEAN JOURNAL OF IMMUNOLOGY | 2011年 / 41卷 / 09期
基金：
日本学术振兴会;
关键词：
Inflammation; Innate immunity; Macrophages; DEMETHYLASE JMJD3 CONTRIBUTES; ALTERNATIVE ACTIVATION; P-TEFB; DIFFERENTIATION; INFLAMMATION; PLASTICITY; MOLECULES; MONOCYTES; INFECTION; RESPONSES;
D O I：
10.1002/eji.201141792
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Epigenetic control of gene expression is critical for cellular differentiation and development. Macrophage development, polarization and activation are also controlled by DNA and histone modifications. This Viewpoint summarizes the recent findings on the role of histone modifications regulating macrophage polarization toward M1 and M2 subtypes.
引用
收藏
页码：2490 / 2493
页数：5
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