Selenium-containing heterocycles:: Synthesis and pharmacological activities of some new 4-methylquinoline-2(1H) selenone derivatives

被引：31

作者：

Abdel-Hafez, Shams H. ^{[1
]}

Hussein, Mostafa A. ^{[2
]}

机构：

[1] Assiut Univ, Fac Sci, Dept Chem, Assiut 71516, Egypt

[2] Assiut Univ, Fac Pharm, Dept Organ Pharmaceut Chem, Assiut, Egypt

来源：

ARCHIV DER PHARMAZIE | 2008年 / 341卷 / 04期

关键词：

fused quinolines; pharmacological screening; pyrimidoselenolo quinolines; quinolines;

D O I：

10.1002/ardp.200700202

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several selenolo[2,3-b]quinolines and pyrimido[4',S':4,5]selenolo[2,3-b]quinolines were prepared by annulations via reaction of NaSeH with 2-chloro-3-cyano-4-methylquinoline 1 followed by reactions with aromatic aldehydes, cycloalkanones, and acetic anhydride. Spectroscopic (IR, H-1-NMR, and MS) properties of the synthesized compounds are reported. Some selected compounds 5a, 7b, 7c, 8b-d, 9a, 11b, and 11d were investigated for their anti-inflammatory and analgesic activities; in addition, the most active compounds were tested for their ulcerogenicity and acute toxicity. Moreover, some of the test compounds 7c, 9a, 11b, and 11d were screened for their antibacterial and antifungal activities.

引用

页码：240 / 246

页数：7

共 30 条

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